J
John R. Ferdinand
Researcher at University of Cambridge
Publications - 48
Citations - 3326
John R. Ferdinand is an academic researcher from University of Cambridge. The author has contributed to research in topics: Immune system & Medicine. The author has an hindex of 18, co-authored 36 publications receiving 1763 citations. Previous affiliations of John R. Ferdinand include National Institute for Health Research & Laboratory of Molecular Biology.
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Journal ArticleDOI
Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors
Matthew D. Young,Thomas J. Mitchell,Thomas J. Mitchell,Thomas J. Mitchell,Felipe A. Vieira Braga,Maxine G. B. Tran,Benjamin J. Stewart,John R. Ferdinand,Grace Collord,Grace Collord,Grace Collord,Rachel A. Botting,Dorin-Mirel Popescu,Kevin W. Loudon,Roser Vento-Tormo,Emily Stephenson,Alex Cagan,Sarah J. Farndon,Sarah J. Farndon,Sarah J. Farndon,Martin Del Castillo Velasco-Herrera,Charlotte Guzzo,Nathan Richoz,Lira Mamanova,Tevita Aho,James N. Armitage,Antony C. P. Riddick,Imran Mushtaq,Stephen Farrell,Dyanne Rampling,James Nicholson,James Nicholson,Andrew Filby,Johanna Burge,Steven Lisgo,Patrick H. Maxwell,Susan Lindsay,Anne Y. Warren,Grant D. Stewart,Grant D. Stewart,Neil J. Sebire,Neil J. Sebire,Nicholas Coleman,Nicholas Coleman,Muzlifah Haniffa,Muzlifah Haniffa,Sarah A. Teichmann,Menna R. Clatworthy,Menna R. Clatworthy,Sam Behjati,Sam Behjati,Sam Behjati +51 more
TL;DR: It is determined that Wilms tumor, a pediatric kidney cancer, originates from aberrant fetal cells, whereas adult kidney cancers are likely derived from a specific subtype of proximal convoluted tubular cell.
Journal ArticleDOI
Mechanisms of Jak/STAT Signaling in Immunity and Disease
TL;DR: This brief review synthesizes the current understanding of Jak/STAT biology while taking stock of the lessons learned and the challenges that lie ahead.
Journal ArticleDOI
A cell atlas of human thymic development defines T cell repertoire formation.
Jong-Eun Park,Rachel A. Botting,Cecilia Domínguez Conde,Dorin-Mirel Popescu,Marieke Lavaert,Daniel J Kunz,Daniel J Kunz,Daniel J Kunz,Issac Goh,Emily Stephenson,Roberta Ragazzini,Roberta Ragazzini,Elizabeth Tuck,Anna Wilbrey-Clark,Kenny Roberts,Veronika R. Kedlian,John R. Ferdinand,Xiaoling He,Simone Webb,Daniel Maunder,Niels Vandamme,Krishnaa T. Mahbubani,Krzysztof Polanski,Lira Mamanova,Liam Bolt,David Crossland,David Crossland,Fabrizio De Rita,Andrew Fuller,Andrew Filby,Gary Reynolds,David Dixon,Kourosh Saeb-Parsy,Steven Lisgo,Deborah J. Henderson,Roser Vento-Tormo,Omer Ali Bayraktar,Roger A. Barker,Kerstin B. Meyer,Yvan Saeys,Paola Bonfanti,Paola Bonfanti,Sam Behjati,Sam Behjati,Menna R. Clatworthy,Menna R. Clatworthy,Menna R. Clatworthy,Tom Taghon,Muzlifah Haniffa,Muzlifah Haniffa,Sarah A. Teichmann,Sarah A. Teichmann +51 more
TL;DR: The authors' single-cell transcriptome profile of the thymus across the human lifetime and across species provides a high-resolution census of T cell development within the native tissue microenvironment, and identifies novel subpopulations of human thymic fibroblasts and epithelial cells and located them in situ.
Journal ArticleDOI
scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation
Elo Madissoon,Elo Madissoon,Anna Wilbrey-Clark,Ricardo J. Miragaia,Kourosh Saeb-Parsy,Krishnaa T. Mahbubani,Nikitas Georgakopoulos,Philippa Harding,Krzysztof Polanski,Ni Huang,Karol Nowicki-Osuch,Rebecca C. Fitzgerald,Kevin W. Loudon,John R. Ferdinand,Menna R. Clatworthy,A. Tsingene,S. van Dongen,Monika Dabrowska,Minal Patel,Michael J. T. Stubbington,Sarah A. Teichmann,Oliver Stegle,Kerstin B. Meyer +22 more
TL;DR: In this article, the effect of cold storage on fresh healthy spleen, esophagus, and lung from ≥ 5 donors over 72h was assessed, and robust protocols for tissue preservation for up to 24h prior to scRNA-seq analysis were presented.
Journal ArticleDOI
Spatiotemporal immune zonation of the human kidney
Benjamin J. Stewart,Benjamin J. Stewart,Benjamin J. Stewart,John R. Ferdinand,Matthew D. Young,Thomas J. Mitchell,Thomas J. Mitchell,Thomas J. Mitchell,Kevin W. Loudon,Kevin W. Loudon,Alexandra M. Riding,Alexandra M. Riding,Nathan Richoz,Gordon L. Frazer,Joy Ursula Lauren Staniforth,Felipe A. Vieira Braga,Rachel A. Botting,Dorin-Mirel Popescu,Roser Vento-Tormo,Emily Stephenson,Alex Cagan,Sarah J. Farndon,Sarah J. Farndon,Sarah J. Farndon,Krzysztof Polanski,Mirjana Efremova,Kile Green,Martin Del Castillo Velasco-Herrera,Charlotte Guzzo,Grace Collord,Grace Collord,Grace Collord,Lira Mamanova,Tevita Aho,James N. Armitage,Antony C. P. Riddick,Imran Mushtaq,Stephen Farrell,Dyanne Rampling,James Nicholson,James Nicholson,Andrew Filby,Johanna Burge,Steven Lisgo,Susan Lindsay,Marc Bajénoff,Anne Y. Warren,Grant D. Stewart,Grant D. Stewart,Neil J. Sebire,Neil J. Sebire,Nicholas Coleman,Nicholas Coleman,Muzlifah Haniffa,Muzlifah Haniffa,Sarah A. Teichmann,Sarah A. Teichmann,Sam Behjati,Sam Behjati,Sam Behjati,Menna R. Clatworthy,Menna R. Clatworthy,Menna R. Clatworthy +62 more
TL;DR: This study provides a global overview of how the immune landscape of the human kidney is zonated to counter the dominant immunological challenge.