M
Martin S. Williamson
Researcher at Rothamsted Research
Publications - 165
Citations - 15089
Martin S. Williamson is an academic researcher from Rothamsted Research. The author has contributed to research in topics: Knockdown resistance & Pyrethroid. The author has an hindex of 59, co-authored 164 publications receiving 12974 citations. Previous affiliations of Martin S. Williamson include University of Hertfordshire & The Hertz Corporation.
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Journal ArticleDOI
Identification of mutations in the housefly para-type sodium channel gene associated with knockdown resistance (kdr) to pyrethroid insecticides
TL;DR: Comparative sequence analysis of housefly strains carrying kdr or the more potentsuper-kdr factor revealed two amino acid mutations that correlate with these resistance phenotypes, and suggest a binding site for pyrethroids at the intracellular mouth of the channel pore in a region known to be important for channel inactivation.
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Amplification of a cytochrome P450 gene is associated with resistance to neonicotinoid insecticides in the aphid Myzus persicae.
Alin M. Puinean,Stephen P. Foster,L. Oliphant,Ian Denholm,Linda M. Field,Neil S. Millar,Martin S. Williamson,Chris Bass +7 more
TL;DR: The mechanisms underlying resistance to the neonicotinoid insecticides were investigated using biological, biochemical, and genomic approaches and it was suggested that P450-mediated detoxification plays a primary role in resistance, although additional mechanism(s) may also contribute.
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A nicotinic acetylcholine receptor mutation conferring target-site resistance to imidacloprid in Nilaparvata lugens (brown planthopper)
TL;DR: Evidence was obtained that demonstrates that mutation Y151S is responsible for a substantial reduction in specific [3H]imidacloprid binding, providing direct evidence for the occurrence of target-site resistance to a neonicotinoid insecticide.
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Detection of knockdown resistance (kdr) mutations in Anopheles gambiae: a comparison of two new high-throughput assays with existing methods
Chris Bass,Dimitra Nikou,Martin J. Donnelly,Martin S. Williamson,Hilary Ranson,Amanda Ball,John Vontas,Linda M. Field +7 more
TL;DR: Two new high-throughput assays were developed and compared with four established techniques for kdr detection, indicating that where maximum sensitivity and specificity are required the TaqMan real-time assay is the preferred method.
Journal ArticleDOI
Mutation of a nicotinic acetylcholine receptor β subunit is associated with resistance to neonicotinoid insecticides in the aphid Myzus persicae
Chris Bass,Alin M. Puinean,Melanie Andrews,Penny Cutler,Miriam Daniels,Jan Elias,Verity Laura Paul,Andrew J. Crossthwaite,Ian Denholm,Linda M. Field,Stephen P. Foster,Rob Lind,Martin S. Williamson,Russell Slater +13 more
TL;DR: This study finds a single point mutation in the loop D region of the nAChR β1 subunit of the resistant clone of M. persicae, causing an arginine to threonine substitution (R81T) and provides further validation of exisiting models of neonicotinoid binding and selectivity for insect nA ChRs.