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Martin S. Williamson

Researcher at Rothamsted Research

Publications -  165
Citations -  15089

Martin S. Williamson is an academic researcher from Rothamsted Research. The author has contributed to research in topics: Knockdown resistance & Pyrethroid. The author has an hindex of 59, co-authored 164 publications receiving 12974 citations. Previous affiliations of Martin S. Williamson include University of Hertfordshire & The Hertz Corporation.

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Ion channels as insecticide targets

TL;DR: It is found that the insecticide-specific pharmacology of some receptors, like that containing subunits of the Rdl encoded GABA receptor, can be reconstituted with very few of the naturally occurring subunits expressed.
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A CRISPR/Cas9 mediated point mutation in the alpha 6 subunit of the nicotinic acetylcholine receptor confers resistance to spinosad in Drosophila melanogaster.

TL;DR: This study uses the CRISPR/Cas9 gene editing platform to introduce the G275E mutation into the nAChR α6 subunit of Drosophila melanogaster, and demonstrates the functional role of this amino acid substitution in resistance to spinosad.
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A single amino acid change makes a rat neuronal sodium channel highly sensitive to pyrethroid insecticides.

TL;DR: It is reported here that substitution of isoleucine for methionine at position 874 (equivalent to the super‐kdr site 918 in the housefly) in the rat IIA α‐subunit causes a 100‐fold increase in sensitivity.
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Reduced alarm response by peach-potato aphids, Myzus persicae (Hemiptera : Aphididae), with knock-down resistance to insecticides (kdr) may impose a fitness cost through increased vulnerability to natural enemies

TL;DR: Overall termite abundance and the abundance of soil-feeders increased between November 1995 and July 1996, reaching a mean of nearly 6000 m -2, which may be due to the beneficial conditioning of soil resulting from the foraging and construction activities of soil -feeders.