M
Martin Schuler
Researcher at La Jolla Institute for Allergy and Immunology
Publications - 9
Citations - 2048
Martin Schuler is an academic researcher from La Jolla Institute for Allergy and Immunology. The author has contributed to research in topics: Apoptosis & Cytochrome c. The author has an hindex of 9, co-authored 9 publications receiving 1960 citations.
Papers
More filters
Journal ArticleDOI
p53 Induces Apoptosis by Caspase Activation through Mitochondrial Cytochrome c Release
TL;DR: It is demonstrated in cells and in vitro that p53 activates the apoptotic machinery through induction of the release of cytochrome c from the mitochondrial intermembrane space.
Journal ArticleDOI
Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation.
TL;DR: Data suggest that caspase-3 is the primary inactivator of DFF45/ICAD and therefore the primary activator of apoptotic DNA fragmentation.
Journal ArticleDOI
Cytochrome C Maintains Mitochondrial Transmembrane Potential and Atp Generation after Outer Mitochondrial Membrane Permeabilization during the Apoptotic Process
Nigel J. Waterhouse,Joshua C. Goldstein,Oliver von Ahsen,Martin Schuler,Donald D. Newmeyer,Douglas R. Green +5 more
TL;DR: It is found that when caspase activity is inhibited, mitochondrial outer membrane permeabilization causes a rapid depolarization of mitochondrial transmembrane potential, which recovers to original levels over the next 30–60 min and is then maintained.
Journal ArticleDOI
Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release.
Ichiro Kuwabara,Yasuko Kuwabara,Ri Yao Yang,Martin Schuler,Douglas R. Green,Bruce L. Zuraw,Daniel K. Hsu,Daniel K. Hsu,Fu-Tong Liu +8 more
TL;DR: Transfectants of HeLa and DLD-1 cells ectopically expressing galectin-7 were found to be more susceptible to apoptosis than control transfectants and this protein is a pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.
Journal ArticleDOI
Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity.
Beni B. Wolf,Martin Schuler,Wei Li,Beth Eggers-Sedlet,Wilson Lee,Pankaj Tailor,Patrick Fitzgerald,Gordon B. Mills,Douglas R. Green +8 more
TL;DR: Regulation of APAF-1 activity may be important for apoptosis regulation in some ovarian cancers because it correlated in some but not all cell lines with resistance to apoptosis.