M
Martin Vreugdenhil
Researcher at RMIT University
Publications - 60
Citations - 2958
Martin Vreugdenhil is an academic researcher from RMIT University. The author has contributed to research in topics: Kainate receptor & Hippocampus. The author has an hindex of 30, co-authored 57 publications receiving 2815 citations. Previous affiliations of Martin Vreugdenhil include Xinxiang Medical University & University of Birmingham.
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Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons
TL;DR: The combined effects of the PUFAs on INa and ICa may reduce neuronal excitability and may exert anticonvulsive effects in vivo.
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Parvalbumin-deficiency facilitates repetitive IPSCs and gamma oscillations in the hippocampus.
TL;DR: It is suggested that PV deficiency, due to an increased short-term facilitation of GABA release, enhances inhibition by high-frequency burst-firing PV-expressing interneurons and may affect the higher cognitive functions associated with gamma oscillations.
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Ictal Epileptiform Activity Is Facilitated by Hippocampal GABAA Receptor-Mediated Oscillations
TL;DR: It is concluded that under epileptogenic conditions, γ band oscillations arise from GABAAergic depolarizations and that this activity may lead to the generation of ictal discharges.
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Parvalbumin deficiency affects network properties resulting in increased susceptibility to epileptic seizures.
Beat Schwaller,Igor V. Tetko,P. Tandon,D. C. Silveira,Martin Vreugdenhil,Thomas Henzi,M. C. Potier,Marco R. Celio,Alessandro E. P. Villa,Alessandro E. P. Villa +9 more
TL;DR: It is postulated that PV plays a key role in the regulation of local inhibitory effects exerted by GABAergic interneurons on pyramidal neurons through an increase in inhibition, the absence of PV facilitates synchronous activity in the cortex and facilitates hypersynchrony through the depolarizing action of GABA in the hippocampus.
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Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model
TL;DR: An infusion of 40 micromol of eicosapentaenoic acid or docosahexaenoic Acid over a period of 30 min, modestly increased the threshold for localized seizure activity after 6 h by 73 +/- 13 microA, and the thresholds for generalized seizure activity by 125 +/- 20 and 130 +/- 19MicroA, respectively (P < 0.001).