M
Martina Bonacini
Researcher at University of Parma
Publications - 31
Citations - 383
Martina Bonacini is an academic researcher from University of Parma. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 8, co-authored 21 publications receiving 220 citations.
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Journal ArticleDOI
EGCG antagonizes Bortezomib cytotoxicity in prostate cancer cells by an autophagic mechanism.
Alice Modernelli,Valeria Naponelli,Maria Giovanna Troglio,Martina Bonacini,Ileana Ramazzina,Saverio Bettuzzi,Federica Rizzi +6 more
TL;DR: It is demonstrated that EGCG antagonizes BZM toxicity by exacerbating the activation of autophagy, which in turn mitigates ER stress and reduces CHOP up-regulation, finally protecting PC3 cells from cell death.
Journal ArticleDOI
Polyphenon E®, a standardized green tea extract, induces endoplasmic reticulum stress, leading to death of immortalized PNT1a cells by anoikis and tumorigenic PC3 by necroptosis
Federica Rizzi,Valeria Naponelli,A. Silva,Alice Modernelli,Ileana Ramazzina,Martina Bonacini,Saverio Tardito,Rita Gatti,Jacopo Uggeri,Saverio Bettuzzi +9 more
TL;DR: Polyphenon E® induced severe ERS in PC3 cells, causing a dramatic enlargement of the ER; persistent activation of UPR produced strong upregulation of GADD153/CHOP, a key protein of ERS-mediated cell death.
Journal ArticleDOI
Cytokine Profiling in Aqueous Humor Samples From Patients With Non-Infectious Uveitis Associated With Systemic Inflammatory Diseases.
Martina Bonacini,Alessandra Soriano,Luca Cimino,Luca De Simone,Elena Bolletta,Fabrizio Gozzi,Francesco Muratore,Maria Nicastro,Lucia Belloni,Alessandro Zerbini,Luigi Fontana,Carlo Salvarani,Stefania Croci +12 more
TL;DR: AH sampling followed by multiplex analysis of cytokines should be fostered in non-infectious uveitis to identify cytokines dysregulated intraocularly in each individual laying the groundwork for precision medicine.
Journal ArticleDOI
Unmet Needs in the Pathogenesis and Treatment of Vasculitides.
Francesco Muratore,Giulia Pazzola,Alessandra Soriano,Nicolò Pipitone,Stefania Croci,Martina Bonacini,Luigi Boiardi,Carlo Salvarani +7 more
TL;DR: Rituximab or anti-TNF alfa may represent a possible alternative therapy in case of refractory or difficult to treat polyarteritis nodosa (PAN) patients and the role of tocilizumab or other biological agents without GCs needs to be investigated.
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Increased expression of interleukin-22 in patients with giant cell arteritis.
Alessandro Zerbini,Francesco Muratore,Luigi Boiardi,Francesco Ciccia,Martina Bonacini,Lucia Belloni,Alberto Cavazza,Luca Cimino,Antonio Moramarco,Riccardo Alessandro,Aroldo Rizzo,Maria Parmeggiani,Carlo Salvarani,Stefania Croci +13 more
TL;DR: IL-22 is increased in patients with GCA and affects viability and gene expression of arterial cells, supporting a potential role in disease pathogenesis.