Saverio Tardito

TL;DR: A critical role for acetate consumption in the production of lipid biomass within the harsh tumor microenvironment is concluded, indicating a critical role in the growth of cancer cell growth under low-oxygen and lipid-depleted conditions.

TL;DR: It is shown here that in glioblastoma (GBM) cells, almost half of the Gln-derived glutamate (Glu) is secreted and does not enter the TCA cycle, and that inhibiting glutaminolysis does not affect cell proliferation.

TL;DR: It is demonstrated that primitive CML cells rely on upregulated oxidative metabolism for their survival, and combination treatment with imatinib and tigecycline, an antibiotic that inhibits mitochondrial protein translation, selectively eradicates CML LSCs both in vitro and in a xenotransplantation model of human CML.

TL;DR: A quantitative structure-activity relationship study of a new class of pyrazole-pyridine copper complexes establishes a clear correlation between the ability to promote copper accumulation and cytotoxicity, and provides a rationale for the exploitation of copper toxicity as an anticancer tool.

TL;DR: It is shown that the commitment of human and murine HSCs to the erythroid lineage is dependent upon glutamine metabolism, which regulates HSC lineage commitment under conditions of metabolic stress.