Martina Comiskey

TL;DR: The data suggest that in the models of colitis studied here the effects of IL-12/Stat-4 or other Th1 promoting pathways are not limited to the induction of IFN-γ gene expression in T lymphocytes, and demonstrate that in some forms of chronic experimental colitis the development of pathogenic T cells is influenced predominantly, though not exclusively, by IL- 12.

TL;DR: The LT pathway plays a role in the development of colitis as important as that of the TNF system and, therefore, represents a potential novel intervention point for the treatment of inflammatory bowel disease.

TL;DR: The CD154/CD40 pathway plays a critical role in Th1-induced chronic experimental colitis and blocking CD154, even after the onset of disease, ameliorates colitis but does not induce a T helper 2 (Th2) phenotype.

TL;DR: Molecular genetics, as well as clinical features, of colon cancer in the beta(2)m(null) x IL-2( null) mice are similar to those of human UC- associated colorectal cancer, and this model appears to be an excellent animal model to study UC-associated coloreCTal carcinogenesis.

TL;DR: In this article, mutations of Apc and p53 genes and microsatellite instability in colonic adenocarcinomas arising in this model were determined by sequencing in 11 colic adnocarcinsomas.