F
Fabienne Mackay
Researcher at University of Melbourne
Publications - 194
Citations - 28135
Fabienne Mackay is an academic researcher from University of Melbourne. The author has contributed to research in topics: B-cell activating factor & B cell. The author has an hindex of 75, co-authored 188 publications receiving 26019 citations. Previous affiliations of Fabienne Mackay include University of New South Wales & Hoffmann-La Roche.
Papers
More filters
Journal ArticleDOI
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Kendle M. Maslowski,Angélica T. Vieira,Angélica T. Vieira,Aylwin Ng,Jan Kranich,Frederic Sierro,Di Yu,Heidi C. Schilter,Heidi C. Schilter,Michael S. Rolph,Fabienne Mackay,Fabienne Mackay,David Artis,Ramnik J. Xavier,Ramnik J. Xavier,Mauro M. Teixeira,Charles R. Mackay +16 more
TL;DR: It is shown that SCFA–GPR43 interactions profoundly affect inflammatory responses, and GPR43 binding of SCFAs potentially provides a molecular link between diet, gastrointestinal bacterial metabolism, and immune and inflammatory responses.
Journal ArticleDOI
Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations.
Fabienne Mackay,Stephen A. Woodcock,Pornsri Lawton,Christine Ambrose,Manfred Baetscher,Pascal Schneider,Jürg Tschopp,Jeffrey L. Browning +7 more
TL;DR: Mice transgenic for BAFF have vastly increased numbers of mature B and effector T cells, and develop autoimmune-like manifestations such as the presence of high levels of rheumatoid factors, circulating immune complexes, anti–DNA autoantibodies, and immunoglobulin deposition in the kidneys.
Journal ArticleDOI
BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.
Pascal Schneider,Fabienne Mackay,Véronique Steiner,Kay Hofmann,Jean Luc Bodmer,Nils Holler,Christine Ambrose,Pornsri Lawton,Sarah A. Bixler,Hans Acha-Orbea,Danila Valmori,Pedro Romero,Christiane Werner-Favre,Rudolph H. Zubler,Jeffrey L. Browning,Jürg Tschopp +15 more
TL;DR: A novel member of the T NF family, designated BAFF (for B cell activating factor belonging to the TNF family), which is expressed by T cells and dendritic cells is described, suggesting that BAFF plays an important role as costimulator of B cell proliferation and function.
Journal ArticleDOI
BAFF AND APRIL: a tutorial on B cell survival.
TL;DR: The BAFF system provides not only potential insight into the development of autoreactive B cells but a relatively simple paradigm to begin considering the balancing act between survival, growth, and death that affects all cells.
Journal ArticleDOI
Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren’s syndrome
Joanna R Groom,Susan L. Kalled,Anne H. Cutler,Carl Olson,Stephen A. Woodcock,Pascal Schneider,Jürg Tschopp,Teresa G. Cachero,Marcel Batten,Julie Wheway,Davide Mauri,Dana Cavill,Tom P. Gordon,Charles R. Mackay,Fabienne Mackay +14 more
TL;DR: It is demonstrated that BAFF Tg mice, as they age, develop a secondary pathology reminiscent of Sjögren's syndrome, and altered B cell differentiation and tolerance induced by excess BAFF may be central to SS pathogenesis.