Ype P. de Jong

TL;DR: It is shown that human occludin (OCLN) is an essential HCV cell entry factor that is able to render murine cells infectable with HCVpp and the identification of OCLN as a new HCV entry factor further highlights the importance of the tight junction complex in the viral entry process.

TL;DR: The establishment of a long-term 3D organoid culture system for mouse and human primary hepatocytes is described, which can be established from single hepatocytes and grown for multiple months, while retaining key morphological, functional and gene expression features.

TL;DR: It is proposed that HCV-induced miR-122 inhibition by HCV RNA may result in global de-repression of host mi R-122 targets, providing an environment fertile for the long-term oncogenic potential of HCV.

TL;DR: This review provides an overview of the type of immune responses that have been documented in animal models and in humans who received gene transfer with one of three widely tested vector systems, namely adenoviral, lentiviral, or adeno-associated viral vectors.

TL;DR: The data suggest that in the models of colitis studied here the effects of IL-12/Stat-4 or other Th1 promoting pathways are not limited to the induction of IFN-γ gene expression in T lymphocytes, and demonstrate that in some forms of chronic experimental colitis the development of pathogenic T cells is influenced predominantly, though not exclusively, by IL- 12.