Martina Tallarico

TL;DR: The results suggest that histone modifications may have a crucial role in the development of epilepsy and early treatment with HDACi might be a possible strategy for preventing epileptogenesis also affecting behavioural comorbidities.

TL;DR: In vivo, NaB confirmed its activity normalizing hepatic biomarkers, fatty acid metabolism, and reducing inflammation and fibrosis induced by VPA, indicating it as valid therapeutic approach in counteracting this common side effect due to VPA chronic treatment.

TL;DR: It seems that cognitive impairment in this strain, similarly to depressive-like behavior, is secondary to the occurrence of absence seizures, which might be necessary for the expression of cognitive impairment, and results suggest an age-dependent impairment of cognitive performance in WAG/Rij rats, which could be linked to the age- dependent increase of spike wave discharges.

TL;DR: In this paper, the authors demonstrate that the gut microbiota is modified and contributes to seizure occurrence in a genetic animal model of absence epilepsy and that its manipulation may be a suitable therapeutic target for absence seizure management.

TL;DR: Ranolazine improved learning and long-term memory in HFD/STZ + Ranolazine compared to HFD or STZ + Vehicle animals and ameliorated the pro-inflammatory profile of diabetic mice, supporting the hypothesis of a protective effect of ranolazine against cognitive decline caused by T2DM.