Mary Chen

TL;DR: By perfusing serotonin onto the synapses made onto one motor neuron, it is found that a single axonal branch can undergo long-term branch-specific facilitation, which depends on CREB-mediated transcription and involves the growth of new synaptic connections exclusively at the treated branch.

TL;DR: Using the bZIP domain of ApC/EBP in a two-hybrid system, ApCREB2, a transcription factor constitutively expressed in sensory neurons that resembles human CREB2 and mouse ATF4, is cloned and has the properties of long-term facilitation.

TL;DR: The short-term process initiated by a single pulse of 5-HT serves not only to produce transient facilitation, but also to mark and stabilize any synapse of the neuron for long-term facilitation by means of a covalent mark and rapamycin-sensitive local protein synthesis.

TL;DR: The morphological basis of the persistent synaptic plasticity that underlies long-term habituation and sensitization of the gill withdrawal reflex in Aplysia californica was explored by examining the fine structure of sensory neuron presynaptic terminals in control animals and in animals whose behavior had been modified by training.

TL;DR: It is found that inhibitors of tPA inhibit the late phase of long-term potentiation (L-LTP) induced by either forskolin or tetanic stimulation in the hippocampal mossy fiber and Schaffer collateral pathways.