Mary G. McMenamin

TL;DR: Normal human bronchial epithelial cells were infected with SV40 virus or an adenovirus 12-SV40 hybrid virus, or transfected via strontium phosphate coprecipitation with plasmids containing the SV40 early region genes, and Colonies of morphologically altered cells were isolated and cultured.

TL;DR: Two phenotypically different subclones provide a new in vitro cellular system for delineating the mechanism(s) of human bronchial epithelial cell squamous differentiation in response to FBS or TGF-beta 1.

TL;DR: One year after injection subcutaneously or intraperitoneally in athymic nude mice, normal human mesothelial cells remain nontumorigenic, and therefore are a potential model system for in vitro fiber carcinogenesis studies.

TL;DR: It is concluded that mutations in the p63 gene are rare in human cell lines, and the fact that DLD1 is abnormal for both p63 and p53 genes suggests that they may not be involved in the same tumor suppressor pathway.

TL;DR: IT is demonstrated that ING2 can act as a cofactor of p300 for p53 acetylation and thereby plays a positive regulatory role during p53-mediated replicative senescence.