S
Stephen Wincovitch
Researcher at National Institutes of Health
Publications - 36
Citations - 1435
Stephen Wincovitch is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Zebrafish & Regeneration (biology). The author has an hindex of 18, co-authored 34 publications receiving 1300 citations. Previous affiliations of Stephen Wincovitch include Hungarian Academy of Sciences.
Papers
More filters
Journal ArticleDOI
Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas
Kevin G. Chen,Julio C. Valencia,Barry Lai,Guofeng Zhang,Jill K. Paterson,Francois Rouzaud,Werner Berens,Stephen Wincovitch,Susan H. Garfield,Richard D. Leapman,Vincent J. Hearing,Michael M. Gottesman +11 more
TL;DR: Evidence is provided that melanosomes contribute to the refractory properties of melanoma cells by sequestering cytotoxic drugs and increasing melanosome-mediated drug export.
Journal ArticleDOI
Multispectral imaging of clinically relevant cellular targets in tonsil and lymphoid tissue using semiconductor quantum dots.
TL;DR: Application of this multiplexing method will enable investigators to explore the clinically relevant multidimensional cellular interactions that underlie diseases, simultaneously.
Journal ArticleDOI
ING2 Regulates the Onset of Replicative Senescence by Induction of p300-Dependent p53 Acetylation
Rémy Pedeux,Sagar Sengupta,Jiang Cheng Shen,Oleg N. Demidov,Shin'ichi Saito,Hitoshi Onogi,Kensuke Kumamoto,Stephen Wincovitch,Susan H. Garfield,Mary G. McMenamin,Makoto Nagashima,Steven R. Grossman,Ettore Appella,Curtis C. Harris +13 more
TL;DR: IT is demonstrated that ING2 can act as a cofactor of p300 for p53 acetylation and thereby plays a positive regulatory role during p53-mediated replicative senescence.
Journal ArticleDOI
Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane.
Jill K. Paterson,Suneet Shukla,Chelsea M. Black,Tokushi Tachiwada,Susan H. Garfield,Stephen Wincovitch,David Ernst,Anissa Agadir,Xuelin Li,Suresh V. Ambudkar,Gergely Szakács,Shin-ichi Akiyama,Michael M. Gottesman +12 more
TL;DR: These studies are the first to demonstrate that ABCB6 exists in two molecular weight forms, is localized to both the outer mitochondrial membrane and the plasma membrane, and plays a functional role in the Plasma membrane.
Journal ArticleDOI
Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation.
Andre M. Pilon,Subramanian S. Ajay,Swathi Ashok Kumar,Laurie A. Steiner,Praveen F. Cherukuri,Stephen Wincovitch,Stacie M. Anderson,James C. Mullikin,Patrick G. Gallagher,Ross C. Hardison,Elliott H. Margulies,David M. Bodine +11 more
TL;DR: The EKLF interactome shows very little overlap with the interactomes of GATA1, GATA2, or TAL1, leading to a model in which EKlF directs programs that are independent of those regulated by the GATA factors or Tal1.