M
Mary G. McMenamin
Researcher at National Institutes of Health
Publications - 25
Citations - 2058
Mary G. McMenamin is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Carcinogenesis & Streptozotocin. The author has an hindex of 15, co-authored 25 publications receiving 2010 citations.
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Journal Article
Transformation of Human Bronchial Epithelial Cells by Infection with SV40 or Adenovirus-12 SV40 Hybrid Virus, or Transfection via Strontium Phosphate Coprecipitation with a Plasmid Containing SV40 Early Region Genes
Roger R. Reddel,Yang Ke,Brenda I. Gerwin,Mary G. McMenamin,John F. Lechner,Robert T. Su,Douglas E. Brash,Joo-Bae Park,Johng S. Rhim,Curtis C. Harris +9 more
TL;DR: Normal human bronchial epithelial cells were infected with SV40 virus or an adenovirus 12-SV40 hybrid virus, or transfected via strontium phosphate coprecipitation with plasmids containing the SV40 early region genes, and Colonies of morphologically altered cells were isolated and cultured.
Journal ArticleDOI
Human bronchial epithelial cells with integrated SV40 virus T antigen genes retain the ability to undergo squamous differentiation
Yang Ke,Roger R. Reddel,Brenda I. Gerwin,Masao Miyashita,Mary G. McMenamin,John F. Lechner,Curtis C. Harris +6 more
TL;DR: Two phenotypically different subclones provide a new in vitro cellular system for delineating the mechanism(s) of human bronchial epithelial cell squamous differentiation in response to FBS or TGF-beta 1.
Journal Article
Establishment of a human in vitro mesothelial cell model system for investigating mechanisms of asbestos-induced mesothelioma.
Yang Ke,Roger R. Reddel,Brenda I. Gerwin,Helen K. Reddel,Angela N. A. Somers,Mary G. McMenamin,Moira A. LaVeck,R. A. Stahel,John F. Lechner,Curtis C. Harris +9 more
TL;DR: One year after injection subcutaneously or intraperitoneally in athymic nude mice, normal human mesothelial cells remain nontumorigenic, and therefore are a potential model system for in vitro fiber carcinogenesis studies.
Journal Article
Mutational Analysis of the p63/p73L/p51/p40/CUSP/KET Gene in Human Cancer Cell Lines Using Intronic Primers
TL;DR: It is concluded that mutations in the p63 gene are rare in human cell lines, and the fact that DLD1 is abnormal for both p63 and p53 genes suggests that they may not be involved in the same tumor suppressor pathway.
Journal ArticleDOI
ING2 Regulates the Onset of Replicative Senescence by Induction of p300-Dependent p53 Acetylation
Rémy Pedeux,Sagar Sengupta,Jiang Cheng Shen,Oleg N. Demidov,Shin'ichi Saito,Hitoshi Onogi,Kensuke Kumamoto,Stephen Wincovitch,Susan H. Garfield,Mary G. McMenamin,Makoto Nagashima,Steven R. Grossman,Ettore Appella,Curtis C. Harris +13 more
TL;DR: IT is demonstrated that ING2 can act as a cofactor of p300 for p53 acetylation and thereby plays a positive regulatory role during p53-mediated replicative senescence.