M
Mary J. Mattapallil
Researcher at National Institutes of Health
Publications - 40
Citations - 2141
Mary J. Mattapallil is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 21, co-authored 38 publications receiving 1728 citations. Previous affiliations of Mary J. Mattapallil include Oregon Health & Science University.
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Journal ArticleDOI
The Rd8 Mutation of the Crb1 Gene Is Present in Vendor Lines of C57BL/6N Mice and Embryonic Stem Cells, and Confounds Ocular Induced Mutant Phenotypes
Mary J. Mattapallil,Eric F. Wawrousek,Chi-Chao Chan,Hui Zhao,Jayeeta Roychoudhury,Thomas A. Ferguson,Rachel R. Caspi +6 more
TL;DR: These findings identify the presence of the rd8 mutation in the C57BL/6N mouse substrain used widely to produce transgenic and knockout mice and in widely used embryonic stem cells, with grave implications for the vision research community who develop mouse lines to study eye disease.
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Clinical-grade stem cell-derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs
Ruchi Sharma,Vladimir Khristov,Aaron Rising,Balendu Shekhar Jha,Roba Dejene,Nathan Hotaling,Yichao Li,Jonathan Stoddard,Casey Stankewicz,Qin Wan,Connie Zhang,Mercedes Campos,Kiyoharu J. Miyagishima,David M. McGaughey,Rafael Villasmil,Mary J. Mattapallil,Boris V. Stanzel,Haohua Qian,Wai T. Wong,Lucas Chase,Steve Charles,Trevor J. McGill,Sheldon S. Miller,Arvydas Maminishkis,Juan Amaral,Kapil Bharti +25 more
TL;DR: The results suggest that the in vitro and in vivo preclinical functional validation of iPSC-RPE patches developed here might ultimately be useful for evaluation and optimization of autologous i PSC-based therapies.
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IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease.
Ivy M. Dambuza,Chang He,Chang He,Jin Kyeong Choi,Cheng-Rong Yu,Renxi Wang,Mary J. Mattapallil,Paul T. Wingfield,Rachel R. Caspi,Charles E. Egwuagu +9 more
TL;DR: In this article, the IL-12p35 subunit has immunoregulatory functions previously attributed to interleukin 35 and Ebi3 subunits, which can be used for in vivo expansion of Breg cells and autologous Breg cell immunotherapy.
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Prior Exposure to Zika Virus Significantly Enhances Peak Dengue-2 Viremia in Rhesus Macaques.
Jeffy George,William G. Valiant,Mary J. Mattapallil,Michelle E. Walker,Yan-Jang S. Huang,Dana L. Vanlandingham,Johnathan Misamore,Jack Greenhouse,Deborah E. Weiss,Daniela Verthelyi,Stephen Higgs,Hanne Leth Andersen,Mark G. Lewis,Joseph J. Mattapallil +13 more
TL;DR: It is shown that prior infection with Zika virus leads to a significant enhancement of Dengue-2 viremia that is accompanied by neutropenia, lympocytosis, hyperglycemia, and higher reticulocyte counts, along with the activation of pro-inflammatory monocyte subsets and release of inflammatory mediators.
Journal ArticleDOI
Mouse Models of Experimental Autoimmune Uveitis
Rachel R. Caspi,Phyllis B. Silver,Dror Luger,Jun Tang,Lizette M. Cortes,Giuseppina Pennesi,Mary J. Mattapallil,Chi-Chao Chan +7 more
TL;DR: The mouse model of experimental autoimmune uveitis, induced by immunization of mice with the retinal protein IRBP, was developed in the laboratory 20 years ago and published in 1988 and its mechanisms are discussed.