M
Mary Matheson
Researcher at Public Health England
Publications - 27
Citations - 732
Mary Matheson is an academic researcher from Public Health England. The author has contributed to research in topics: Vaccination & Tetanus. The author has an hindex of 13, co-authored 23 publications receiving 643 citations. Previous affiliations of Mary Matheson include Salisbury University & Health Protection Agency.
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Journal ArticleDOI
Antibody Responses After Primary Immunization in Infants Born to Women Receiving a Pertussis-containing Vaccine During Pregnancy: Single Arm Observational Study With a Historical Comparator
Shamez N Ladhani,Nick Andrews,Jo Southern,Christine E. Jones,Gayatri Amirthalingam,Pauline Waight,Anna England,Mary Matheson,Xilian Bai,Helen Findlow,Polly Burbidge,Vasili Thalasselis,Bassam Hallis,David Goldblatt,Ray Borrow,Paul T. Heath,Elizabeth Miller +16 more
TL;DR: Antenatal pertussis immunization results in high infant pre-immunization antibody concentrations, but blunts subsequent responses to pertussi vaccine and some CRM-conjugated antigens.
Journal ArticleDOI
Recombinant Neisseria meningitidis Transferrin Binding Protein A Protects against Experimental Meningococcal Infection
David Mckay West,Karen M. Reddin,Mary Matheson,Robert Heath,Simon G. P. Funnell,Michael J. Hudson,Andrew Robinson,Andrew Gorringe +7 more
TL;DR: It is demonstrated that TbpA used as a vaccine antigen may provide protection against a wider range of meningococcal strains than does TbpB alone, and indicates that serum bactericidal activity may not always be the most appropriate predictor of efficacy for protein-based meningitis vaccines.
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Nasopharyngeal Colonization by Neisseria lactamica and Induction of Protective Immunity against Neisseria meningitidis
Cariad Evans,Catherine B. Pratt,Mary Matheson,Thomas E. Vaughan,Jamie Findlow,Ray Borrow,Andrew Gorringe,Robert C. Read +7 more
TL;DR: Carriers of N. lactamica develop mucosal and systemic humoral immunity to N. meningitidis carriage, independent ofhumoral immunity, and some individuals are intrinsically resistant to Nmeningitidis.
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Phase I Safety and Immunogenicity Study of a Candidate Meningococcal Disease Vaccine Based on Neisseria lactamica Outer Membrane Vesicles
Andrew Gorringe,Stephen Taylor,Charlotte Brookes,Mary Matheson,Michelle Finney,Moyra Kerr,Michael J. Hudson,Jamie Findlow,Ray Borrow,Nick Andrews,George Kafatos,Cariad Evans,Robert C. Read +12 more
TL;DR: The N. lactamica OMV vaccine is safe and induces a weak but broad humoral immune response to N. meningitidis, and was immunogenic, eliciting rises in titers of immunoglobulin G (IgG) against the vaccine OMVs, together with a significant booster response as determined by an enzyme-linked immunosorbent assay.
Journal ArticleDOI
The development of a meningococcal disease vaccine based on Neisseria lactamica outer membrane vesicles.
Andrew Gorringe,Denise Halliwell,Mary Matheson,Karen M. Reddin,Michelle Finney,Michael J. Hudson +5 more
TL;DR: Pre-clinical data indicate that N. lactamica outer membrane vesicles (OMVs) may provide a vaccine effective against diverse disease-causing meningococcal strains, and the vaccine is currently being manufactured and validated ELISA protocols have been developed for the analysis of serological responses.