Mary Pinkerton

TL;DR: The molecular structure by X-ray crystallography of this cyclododecadepsipeptide as the potassium aurichloride complex is determined, and it is found to be wrapped around the potassium ion coordinated to the oxygen atoms of alternate carbonyl groups, held together by hydrogen bonding, and holding the anion less specifically.

TL;DR: The molecular structure and the cation binding of nigericin, an antibiotic affecting ion transport and ATPase activity in mitochondria, has been determined by single crystal X-ray crystallography and is found to be similar to monensin.

TL;DR: The nature of the structure of the complex suggests that the biological effects of monensin may well be a consequence of the ability of the antibiotic to make sodium and potassium soluble in lipid portions of cellular structures.

TL;DR: The X-ray crystallography of monovalent metal cations with the antibiotics monensins, nigericin, and dianemycin has been shown to be functionally similar.