Masahiko Taniguchi

TL;DR: The results suggest that GISTs may be divided into mutation-positive and -negative subtypes and that mutation of the c-kit gene may be a good prognostic marker of Gists.

TL;DR: Familial gastrointestinal stromal tumours with germline mutation of the KIT gene is reported: affected members all have a KIT mutation occurring between the transmembrane and tyrosine kinase domains, which is also the region where mutations have been found in solitary GISTs

TL;DR: The aims of the present study were to examine the frequency of the extracellular domain mutation of the c‐kit gene and to determine whether the mutation is a gain‐of‐function type or not, and whether the prognosis of the patients with the Extracellular Domain mutation was comparable to that of the Patients with the juxtamembrane domain mutation.

TL;DR: This study transfected mutant c-kit cDNA into an interleukin 3-dependent Ba/F3 murine lymphoid cell line, and the magnitude of autophosphorylation of the mutant KIT was examined with or without stem cell factor, a ligand of KIT.

TL;DR: This is the first report of familial dysphagia caused by germline gain-of-function mutation of the KIT gene at the TK II domain, found in a family with multiple gastrointestinal stromal tumors.