Masakazu Kuroko

TL;DR: A large accumulation made the membrane structure unstable, resulting in the release of membrane fragments and the simultaneous enhancement of permeability, and the action mechanism of gramicidin S and melittin was compared with that of simple surfactants.

TL;DR: The present results show that both the peptides have the ability to stimulate the release of membrane fragments out of the cells and this brings about the perforation of molecules of small size, leading to a colloid-osmotic hemolysis.

TL;DR: Results indicate that mastoparan penetrated into membranes mainly containing acidic phospholipids and disrupted the membrane structure to increase the permeability.

TL;DR: A choline-sensitive membrane electrode made with potassium tetrakis(p -chlorophenyl) borate as the exchanger and o -nitrophenyl phenyl ether as membrane solvent in poly (vinyl chloride) was almost insensitive to the surfactant sodium deoxycholate as discussed by the authors.

TL;DR: The following mechanism was proposed to explain the permeability-increasing action of Azone: the agent entered into erythrocyte membrane and made the membrane structure unstable, resulting in both the release of membrane fragments outside cells and the enhancement of permeability.