Masaki Hiramoto

TL;DR: The layer‐specific projections of the hindbrain and retinal axons suggest a functional segregation of sensory inputs to proximal and distal tectal cell dendrites, respectively.

TL;DR: The idea that retinal waves in amniotes, the animals that develop either in ovo or utero (namely reptiles, birds and mammals) could be an evolutionary adaptation to life on land is contemplated, and it is predicted that the experience-dependent development of the tadpole visual system is a blueprint of what will be found in future studies of the effects of spontaneousretinal waves on instructing development of retinorecipient targets.

TL;DR: It is demonstrated that a spatial to temporal to spatial transformation of visual information controls experience-dependent topographic map plasticity, and is likely to apply to other sensory modalities and projections in the brain.

TL;DR: It is found that developing inhibitory neurons fall into distinct functional groups with opposite experience-dependent plasticity and as such, are well positioned to foster experience- dependent synaptic Plasticity and maintain circuit stability during labile periods of circuit development.

TL;DR: In this paper, the authors used a panel of truncated mutants to identify a new player in TDP-43 cytoplasmic-nuclear transport, and showed that dysregulation of DCTN1-TDP43 interactions triggers mislocalization and aggregation of TDP43, thus providing insights into the pathological mechanisms of Perry disease.