J
Junichi Yuasa-Kawada
Researcher at Fukuoka University
Publications - 9
Citations - 216
Junichi Yuasa-Kawada is an academic researcher from Fukuoka University. The author has contributed to research in topics: Slit & Axon guidance. The author has an hindex of 5, co-authored 9 publications receiving 176 citations. Previous affiliations of Junichi Yuasa-Kawada include Northwestern University & Okinawa Institute of Science and Technology.
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Journal ArticleDOI
Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration
Junichi Yuasa-Kawada,Mariko Kinoshita-Kawada,Mariko Kinoshita-Kawada,Yi Rao,Yi Rao,Jane Y. Wu,Jane Y. Wu +6 more
TL;DR: It is shown that ubiquitin-specific protease 33 (USP33)/VDU1, originally identified as a von Hippel–Lindau tumor suppressor (VHL) protein-interacting deubiquitinating enzyme, binds to the Robo1 receptor, and that USP33 is required for Slit responsiveness in breast cancer cells.
Journal ArticleDOI
Midline crossing and Slit responsiveness of commissural axons require USP33
TL;DR: This work found that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor, revealing a previously unknown role for USP 33 in vertebrate commissural axon guidance and in Slit signaling.
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A crucial role for Arf6 in the response of commissural axons to Slit
Mariko Kinoshita-Kawada,Mariko Kinoshita-Kawada,Mariko Kinoshita-Kawada,Hiroshi Hasegawa,Tsunaki Hongu,Shigeru Yanagi,Yasunori Kanaho,Ichiro Masai,Takayasu Mishima,Xiaoping Chen,Yoshio Tsuboi,Yi Rao,Junichi Yuasa-Kawada,Jane Y. Wu +13 more
TL;DR: It is found that a Robo1 endocytosis-triggered and Arf6-mediated positive-feedback strengthens the Slit response in commissural axons upon their midline crossing and provides insights into endocytic trafficking-mediated mechanisms for spatiotemporally controlled axonal responses.
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The BH3-Only SNARE BNip1 Mediates Photoreceptor Apoptosis in Response to Vesicular Fusion Defects
Yuko Nishiwaki,Asuka Yoshizawa,Yutaka Kojima,Eri Oguri,Shohei Nakamura,Shohei Suzuki,Junichi Yuasa-Kawada,Mariko Kinoshita-Kawada,Toshiaki Mochizuki,Ichiro Masai +9 more
TL;DR: It is reported that photoreceptors undergo apoptosis in a zebrafish β-soluble N-ethylmaleimide-sensitive factor attachment protein (β-SNAP) mutant and that BNip1 transforms vesicular fusion defects into photoreceptor apoptosis, suggesting that the syntaxin-18 cis-SNARE complex functions as an alarm factor that monitors vesicle fusion competence.
Journal ArticleDOI
Dctn1 binds to tdp-43 and regulates tdp-43 aggregation
Manami Deshimaru,Mariko Kinoshita-Kawada,Kaori Kubota,Takuya Watanabe,Yasuyoshi Tanaka,Saito Hirano,Fumiyoshi Ishidate,Masaki Hiramoto,Mitsuru Ishikawa,Yoshinari Uehara,Hideyuki Okano,Shinichi Hirose,Shinsuke Fujioka,Katsunori Iwasaki,Junichi Yuasa-Kawada,Takayasu Mishima,Yoshio Tsuboi +16 more
TL;DR: In this paper, the authors used a panel of truncated mutants to identify a new player in TDP-43 cytoplasmic-nuclear transport, and showed that dysregulation of DCTN1-TDP43 interactions triggers mislocalization and aggregation of TDP43, thus providing insights into the pathological mechanisms of Perry disease.