Yasuyoshi Tanaka

TL;DR: Developing a genome-edited control cell line from this DS iPSC line by substituting the point mutation with the wild-type residue will be a powerful tool for research into the pathology of DS.

TL;DR: In this paper, the authors used a panel of truncated mutants to identify a new player in TDP-43 cytoplasmic-nuclear transport, and showed that dysregulation of DCTN1-TDP43 interactions triggers mislocalization and aggregation of TDP43, thus providing insights into the pathological mechanisms of Perry disease.

TL;DR: A novel knock-in system that circumvents several traditional challenges by establishing stem cells with acceptor elements enveloping a particular genomic target and can readily generate mice bearing various mutations, making it a suitable feeder technology toward streamlined phenotyping is developed.

TL;DR: The application of iPSCs in epilepsy provides insight into novel treatments based on the molecular pathomechanisms of epilepsy, and the generation of neuronal organoids, or "mini brains," has the potential for extensive epilepsy research opportunities.

TL;DR: In this paper, the authors used a microelectrode array-based assay to find that patient-derived iPSC GABA neurons exhibited dysfunctional maturation with reduced numbers of spontaneous spikes and bursts.