M
Masako Seki
Researcher at Kagawa University
Publications - 23
Citations - 2439
Masako Seki is an academic researcher from Kagawa University. The author has contributed to research in topics: Galectin & Eosinophil. The author has an hindex of 16, co-authored 23 publications receiving 2276 citations. Previous affiliations of Masako Seki include Brigham and Women's Hospital & La Jolla Institute for Allergy and Immunology.
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Journal ArticleDOI
Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis
Masako Seki,Souichi Oomizu,Ken Mei Sakata,Atsuko Sakata,Tomohiro Arikawa,Kota Watanabe,Kanako Ito,Keisuke Takeshita,Toshiro Niki,Naoki Saita,Nozomu Nishi,Akira Yamauchi,Shigeki Katoh,Akihiro Matsukawa,Vijay K. Kuchroo,Mitsuomi Hirashima +15 more
TL;DR: It is suggested that galectin-9 ameliorates CIA by suppressing the generation of Th17, promoting the induction of regulatory T cells, and it suppresses differentiation to Th17 cells in vitro.
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Human ecalectin, a variant of human galectin-9, is a novel eosinophil chemoattractant produced by T lymphocytes
Ryoji Matsumoto,Hiroyuki Matsumoto,Masako Seki,Mitsumi Hata,Yusuke Asano,Shiro Kanegasaki,Richard L. Stevens,Mitsuomi Hirashima +7 more
TL;DR: The finding that the ecalectin transcript is present in abundance in various lymphatic tissues and that its expression increases substantially in antigen-activated peripheral blood mononuclear cells suggests that ecalECTin is an important T-cell-derived regulator of eosinophil recruitment in tissues during inflammatory reactions.
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Galectin-9 Induces Apoptosis Through the Calcium-Calpain-Caspase-1 Pathway
Yumiko Kashio,Kazuhiro Nakamura,Mohammad J. Abedin,Masako Seki,Nozomu Nishi,Naoko Yoshida,Takanori Nakamura,Mitsuomi Hirashima +7 more
TL;DR: Gal-9 induces apoptosis via the Ca2+-calpain-caspase-1 pathway, and that Gal-9 plays a role in immunomodulation of T cell-mediated immune responses is suggested.
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Possible role of galectin-9 in cell aggregation and apoptosis of human melanoma cell lines and its clinical significance.
Toshiro Kageshita,Yumiko Kashio,Akira Yamauchi,Masako Seki,Mohammad J. Abedin,Nozomu Nishi,Hiroki Shoji,Takanori Nakamura,Tomomichi Ono,Mitsuomi Hirashima +9 more
TL;DR: High galectin‐9 expression was inversely correlated with the progression of this disease, suggesting that high galect in‐depth expression in primary melanoma lesions links to a better prognosis.
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Galectin-9 as a prognostic factor with antimetastatic potential in breast cancer.
Akemi Irie,Akira Yamauchi,Keiichi Kontani,Minoru Kihara,Dage Liu,Yukako Shirato,Masako Seki,Nozomu Nishi,Takanori Nakamura,Hiroyasu Yokomise,Mitsuomi Hirashima +10 more
TL;DR: Multivariate analysis revealed that galectin-9 status influenced distant metastasis independently of and to a greater extent than lymph node metastasis in patients with breast cancer.