Masami Ohnishi

TL;DR: The modifying effects of two natural products, curcumin and hesperidin, given during the initiation and postinitiation phases of oral carcinogenesis initiated with 4-nitroquinoline 1-oxide (4-NQO) were investigated in male F344 rats and compared with that of beta-carotene as discussed by the authors.

TL;DR: The results indicate that AX and CX are possible chemopreventers for oral carcinogenesis, and such effects may be partly due to suppression of cell proliferation.

TL;DR: In this article, the modulating effects of dietary feeding of two xanthophylls, astaxanthin (AX) and canthaxantha (CX), during the post-initiation phase on colon carcinogenesis initiated with azoxymethane (AOM) were investigated in male F344 rats.

TL;DR: It is suggested that supplementation with the flavonoids diosmin and hesperidin, individually and in combination, is effective in inhibiting the development of oral neoplasms induced by 4-NQO, and such inhibition might be related to suppression of increased cell proliferation caused by 5-nitroquinoline 1-oxide in the oral mucosa.

TL;DR: The modifying effects of three doses of dietary protocatechuic acid (PCA) given the initiation and postinitiation phases of oral carcinogenesis initiated with 4-nitroquinoline 1-oxide (4-NQO) were investigated in male F344 rats as discussed by the authors.