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Akira Hara
Researcher at Gifu University
Publications - 378
Citations - 11666
Akira Hara is an academic researcher from Gifu University. The author has contributed to research in topics: Reductase & Enzyme. The author has an hindex of 51, co-authored 367 publications receiving 10280 citations.
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Journal ArticleDOI
Aldehyde dehydrogenase 1A1 in stem cells and cancer
TL;DR: The functions and mechanisms of ALDH1A1, the key ALDH isozyme linked to SC populations and an important contributor to CSC function in cancers, are reviewed, and its potential in future anticancer strategies is outlined.
Journal ArticleDOI
Nerve growth factor promotes gastric tumorigenesis through aberrant cholinergic signaling
Yoku Hayakawa,Yoku Hayakawa,Kosuke Sakitani,Mitsuru Konishi,Samuel Asfaha,Samuel Asfaha,Ryota Niikura,Hiroyuki Tomita,Bernhard W. Renz,Bernhard W. Renz,Yagnesh Tailor,Marina Macchini,Moritz Middelhoff,Zhengyu Jiang,Takayuki Tanaka,Zinaida A. Dubeykovskaya,Woosook Kim,Xiaowei Chen,Aleksandra M. Urbanska,Karan Nagar,Christoph B. Westphalen,Christoph B. Westphalen,Michael Quante,Chyuan Sheng Lin,Michael D. Gershon,Akira Hara,Chun-Mei Zhao,Duan Chen,Daniel L. Worthley,Daniel L. Worthley,Kazuhiko Koike,Timothy C. Wang +31 more
TL;DR: It is found that Dclk1+ tuft cells and nerves are the main sources of acetylcholine (ACh) within the gastric mucosa and this feedforward ACh-NGF axis activates the Gastric cancer niche and offers a compelling target for tumor treatment and prevention.
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Chemoprevention of azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin.
Takuji Tanaka,Hiroki Makita,Kunihiro Kawabata,Hideki Mori,Mikio Kakumoto,Kumiko Satoh,Akira Hara,T Sumida,H Ogawa +8 more
TL;DR: Results indicate that diosmin and hesperidin, both alone and in combination, act as a chemopreventive agent against colon carcinogenesis, and such effects may be partly due to suppression of cell proliferation in the colonic crypts, although precise mechanisms should be clarified.
Journal ArticleDOI
Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche
Yoku Hayakawa,Hiroshi Ariyama,Jitka Stancikova,Kosuke Sakitani,Samuel Asfaha,Bernhard W. Renz,Bernhard W. Renz,Zinaida A. Dubeykovskaya,Wataru Shibata,Hongshan Wang,Christoph B. Westphalen,Xiaowei Chen,Yoshihiro Takemoto,Woosook Kim,Shradha S. Khurana,Yagnesh Tailor,Karan Nagar,Hiroyuki Tomita,Akira Hara,Antonia R. Sepulveda,Wanda Setlik,Michael D. Gershon,Subhrajit Saha,Lei Ding,Zeli Shen,James G. Fox,Richard A. Friedman,Stephen F. Konieczny,Daniel L. Worthley,Vladimir Korinek,Timothy C. Wang +30 more
TL;DR: It is shown that Mist1 expression marks quiescent stem cells in the gastric corpus isthmus, providing targets within the neoplastic gastric stem cell niche.
Journal ArticleDOI
The inhibitory effects of mangiferin, a naturally occurring glucosylxanthone, in bowel carcinogenesis of male F344 rats.
Naoki Yoshimi,Kengo Matsunaga,Masaki Katayama,Yasuhiro Yamada,Toshiya Kuno,Zheng Qiao,Akira Hara,Johji Yamahara,Hideki Mori +8 more
TL;DR: The results suggest that mangiferin has potential as a naturally-occurring chemopreventive agent.