M
Masamichi Ohgushi
Researcher at Kumamoto University
Publications - 38
Citations - 2907
Masamichi Ohgushi is an academic researcher from Kumamoto University. The author has contributed to research in topics: Endothelium & Angina. The author has an hindex of 29, co-authored 38 publications receiving 2844 citations.
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Journal ArticleDOI
Vitamin E administration improves impairment of endothelium-dependent vasodilation in patients with coronary spastic angina
Takeshi Motoyama,Hiroaki Kawano,Kiyotaka Kugiyama,Osamu Hirashima,Masamichi Ohgushi,Ryusuke Tsunoda,Yasushi Moriyama,Yuji Miyao,Michihiro Yoshimura,Hisao Ogawa,Hirofumi Yasue +10 more
TL;DR: It is indicated that vitamin E treatment improved endothelium-dependent vasodilation and decreased plasma TBARS levels in patients with CSA, and increased oxidative stress may contribute to endothelial dysfunction and anginal attacks in patientswith CSA.
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Impairment of endothelium-dependent relaxation of rabbit aortas by cigarette smoke extract—role of free radicals and attenuation by captopril
Yasutaka Ota,Kiyotaka Kugiyama,Seigo Sugiyama,Masamichi Ohgushi,Toshiyuki Matsumura,Hideki Doi,Nobuhiko Ogata,Hideki Oka,Hirofumi Yasue +8 more
TL;DR: The results indicate that free radicals in CSE induce the impairment of EDR, which may be partly due to suppression of NO production and is not due to non-specific cytotoxicity by CSE.
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Transferable lipids in oxidized low-density lipoprotein stimulate plasminogen activator inhibitor-1 and inhibit tissue-type plasminogen activator release from endothelial cells.
Kiyotaka Kugiyama,Tomohiro Sakamoto,Ikuo Misumi,Seigo Sugiyama,Masamichi Ohgushi,Hisao Ogawa,Masaaki Horiguchi,Hirofumi Yasue +7 more
TL;DR: To determine whether oxidized low- density lipoprotein (Ox-LDL), which accumulates in atherosclerotic arteries, modulates the endothelial fibrinolytic system, cultures of human umbilical vein endothelial cells were incubated with low-density lipoproteins or lipids.
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Cigarette smoke extract contracts isolated porcine coronary arteries by superoxide anion-mediated degradation of EDRF
TL;DR: CSE induced biphasic tension change, initial contraction, and subsequent relaxation during stable contraction to PGF2 alpha in isolated pig coronary arteries, mediated through the degradation of basally released endothelium-derived relaxing factor (nitric oxide) by superoxide anions derived from CSE.
Journal ArticleDOI
Deficiency in nitric oxide bioactivity in epicardial coronary arteries of cigarette smokers.
Kiyotaka Kugiyama,Hirofumi Yasue,Masamichi Ohgushi,Takeshi Motoyama,Hiroaki Kawano,Yoshito Inobe,Osamu Hirashima,Seigo Sugiyama +7 more
TL;DR: Nitric oxide bioactivity at rest and at acetylcholine-stimulated conditions in smokers was decreased, leading to the supersensitivity of the artery to the dilator effect of nitroglycerin as well as the constrictor effect of acetyl choline in smokers.