K
Kiyotaka Kugiyama
Researcher at Kumamoto University
Publications - 126
Citations - 11251
Kiyotaka Kugiyama is an academic researcher from Kumamoto University. The author has contributed to research in topics: Angina & Coronary arteries. The author has an hindex of 50, co-authored 125 publications receiving 10957 citations.
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Journal ArticleDOI
Localization and mechanism of secretion of B-type natriuretic peptide in comparison with those of A-type natriuretic peptide in normal subjects and patients with heart failure.
Hirofumi Yasue,Michihiro Yoshimura,Hitoshi Sumida,Koichi Kikuta,Kiyotaka Kugiyama,Michihisa Jougasaki,Hisao Ogawa,Ken Okumura,Masashi Mukoyama,Kazuwa Nakao +9 more
TL;DR: Examination of the sources and mechanisms of the secretion of BNP in comparison with those of ANP in control subjects and in patients with heart failure concludes that BNP is secreted mainly from the left ventricle in normal adult humans as well as in Patients with left ventricular dysfunction.
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T−786→C Mutation in the 5′-Flanking Region of the Endothelial Nitric Oxide Synthase Gene Is Associated With Coronary Spasm
Masafumi Nakayama,Hirofumi Yasue,Michihiro Yoshimura,Yukio Shimasaki,Kiyotaka Kugiyama,Hisao Ogawa,Takeshi Motoyama,Yoshihiko Saito,Yoshihiro Ogawa,Yoshihiro Miyamoto,Kazuwa Nakao +10 more
TL;DR: Findings strongly suggest that the T-786-->C mutation in the eNOS gene reduces the endothelial NO synthesis and predisposes the patients with the mutation to coronary spasm.
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Hyperglycemia rapidly suppresses flow-mediated endothelium- dependent vasodilation of brachial artery
Hiroaki Kawano,Takeshi Motoyama,Osamu Hirashima,Nobutaka Hirai,Yuji Miyao,Tomohiro Sakamoto,Kiyotaka Kugiyama,Hisao Ogawa,Hirofumi Yasue +8 more
TL;DR: Hyperglycemia in response to oral glucose loading rapidly suppresses endothelium-dependent vasodilation, probably through increased production of oxygen-derived free radicals, and these findings strongly suggest that prolonged and repeated post-prandial hyper glycemia may play an important role in the development and progression of atherosclerosis.
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Induction of coronary artery spasm by acetylcholine in patients with variant angina: possible role of the parasympathetic nervous system in the pathogenesis of coronary artery spasm.
Hirofumi Yasue,Yutaka Horio,Natsuki Nakamura,Hiromi Fujii,Nobuya Imoto,Ryuji Sonoda,Kiyotaka Kugiyama,Kenji Obata,Yasuhiro Morikami,Tadashi Kimura +9 more
TL;DR: It is concluded that the intracoronary injection of ACh induces coronary spasm and attack in patients with variant angina and that the activity of the parasympathetic nervous system may play a role in the pathogenesis of coronary spasms.
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A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese
Michihiro Yoshimura,Hirofumi Yasue,Masafumi Nakayama,Yukio Shimasaki,Hitoshi Sumida,Seigo Sugiyama,Kiyotaka Kugiyama,Hisao Ogawa,Yoshihiro Ogawa,Yoshihiko Saito,Yoshihiro Miyamoto,Kazuwa Nakao +11 more
TL;DR: The missense Glu298Asp variant in the eNOS gene is found by the analysis of its entire 26 coding regions and is significantly associated with coronary spasm.