Showing papers in "Atherosclerosis in 1997"

TL;DR: Lumbar aortic calcification can be graded and composite summary scores are reproducible and this technique appears to provide a simple, low cost assessment of subclinical vascular disease.

TL;DR: The present findings suggest that the impairment of FMD in the brachial artery, a marker of systemic endothelial function, is closely related to the angiographic extent of CAD.

TL;DR: Low ABI levels, particularly those of < 0.90, are indicative of generalized atherosclerosis, and are attenuated and often not statistically significant after further adjustment for LDL cholesterol, cigarette smoking, hypertension and diabetes.

TL;DR: Results suggest that HMG-CoA reductase inhibitors exert a direct antiatherosclerotic effect in the arterial wall, beyond their effects on plasma lipids, that could translate into a more significant prevention of cardiovascular disease.

TL;DR: It is shown that antioxidant compounds in red wine can associate with LDL particles following an incubation in whole plasma, can exert an antioxidant effect and, in so doing, can inhibit the uptake of the lipoprotein by macrophages.

TL;DR: This study demonstrates the large and consistent impact of the thermolabile MTHFR variant on plasma homocysteine levels in different European populations, and shows a regional difference in the levels of homocy steine that must be explained by other genetic or environmental factors.

TL;DR: This review focuses only on NIDDM, a type of diabetes mellitus known to be associated with several adverse cardiovascular risk factors, including hypertension, obesity, central obesity, hyperinsulinemia and serum lipid and lipoprotein abnormalities.

TL;DR: The mucin-like glycoprotein ligand for P-selectin (PSGL-1) bears Oand N-linked carbohydrates, and is found on neutrophils, natural killer cells, monocytes and T-lymphocytes, giving rise to the hypothesis that it is involved in an interaction between these leukocytes and the endothelium.

TL;DR: Dietary flax seed supplementation is effective in reducing hypercholesterolemic atherosclerosis markedly without lowering serum cholesterol and could prevent hypercholesterololemia-related heart attack and strokes.

TL;DR: In young men with coronary artery disease, oral L-arginine improves endothelium-dependent dilatation and reduces monocyte/endothelial cell adhesion, and in humans with established atherosclerosis, this effect is unknown.

TL;DR: A transition within the LPL promoter at position-93 may lead to increased LPL activity and have a beneficial effect on plasma lipids, which may be of considerable importance in understanding genetic predisposition to atherosclerosis and heart disease.

TL;DR: The antiatherogenic properties of fluvastatin may not be limited to its hypocholesterolemic effect, but could also be related to its ability to reduce LDL oxidizability.

TL;DR: The results of the present study raise the question whether LDL oxidizability (at least when tested at high induction rate ex vivo) is a primary causal mechanism in atherosclerosis in the cholesterol-fed rabbit.

TL;DR: Although apoptosis clearly takes place in atherosclerotic plaques, oncosis appears to be a much more common mechanism for cell death.

TL;DR: This study shows that smokers are both insulin resistant and lipid intolerant, and the postprandial lipid intolerance is also seen in individuals with normal fasting triglyceride levels and is related to an increased prevalence of atherogenic small dense LDL.

TL;DR: It is demonstrated that, in subjects with asymptomatic early atherosclerosis, the plasma levels of markers of systemic leukocyte activation were correlated with age and blood pressure, and were higher in smokers and hypertensives.

TL;DR: In this article, it was shown that increased mitochondrial beta-oxidation with a concomitant decrease in triglyceride synthesis and secretion seems to be the primary mechanism underlying the hypotriglyceridemic effect of fish oil and fibrates in rats, rabbits and possibly also in humans.

TL;DR: With modern immunohistochemical and molecular-biological methods, the cholesterol-fed rabbit can be used to investigate the pathophysiological aspects which also contribute to human atherosclerosis, such as lipoproteins, diabetes, mitogens, growth-factors, adhesion molecules, endothelial-function, receptor-pathways or platelets.

TL;DR: The data suggests that Fas/APO 1 regulated apoptosis is involved in the development of advanced human atherosclerotic lesions and that it probably determines the amount of tissue mass in the diseased vessels.

TL;DR: The results indicate that free radicals in CSE induce the impairment of EDR, which may be partly due to suppression of NO production and is not due to non-specific cytotoxicity by CSE.

TL;DR: Fibrates regulate plasma HDL concentrations, at least partly, due to their effects on apo A-I gene transcription, and the beneficial effects of fibrates on lipoprotein metabolism are independent of any undesirable proliferation of peroxisomes.

TL;DR: It is indicated that homozygosity for the 677C-->T MTHFR mutation, especially in combination with low folate status, predisposes to high plasma levels of fasting tHcy and was not associated with increased risk of coronary artery disease.

TL;DR: Results confirm that lipid peroxidation resistance in serum or plasma are associated with ascorbic acid, urate, alpha-tocopherol, albumin and HDL concentrations.

TL;DR: The biochemical and cellular effects of copper ions that may play a role in atherogenesis are reviewed and it is shown that changes in body copper status are difficult to predict.

TL;DR: Atorvastatin 10 and 20mg once daily is superior to pravastatin 20 and 40 mg once daily in treating patients with hypercholesterolemia and neither treatment caused clinically relevant laboratory abnormalities.

TL;DR: The data suggest that sICAM-1 and sVCam-1 are useful as indices of clinical manifestations of atherosclerosis and aging, respectively.

TL;DR: Results suggest increased in vivo oxidative stress and inflammation in DM and smoking, which is partly overcome by vitamin E.

TL;DR: The results suggest that the inhibition of migration and proliferation of VSMCs contributes to the inhibitory effect of estrogen on intimal thickening.

TL;DR: TF activity was detected in each lesion and was more prominent in fatty streaks and atheromatous plaques than in the diffuse intimal thickening, indicating that active TF is expressed in the early stage of atherosclerotic lesions as well as in the advanced stage, and it contributes to the thrombotic property of human atherosclerosis.

TL;DR: GRIPS is the first prospective cohort study which clearly justifies the key role of LDL cholesterol in preventive strategies and gives strong support for the additional consideration of other risk factors for a valid estimation of the MI risk for an individual subject.