M
Masaru Yamaizumi
Researcher at Kumamoto University
Publications - 49
Citations - 3372
Masaru Yamaizumi is an academic researcher from Kumamoto University. The author has contributed to research in topics: Xeroderma pigmentosum & DNA repair. The author has an hindex of 29, co-authored 49 publications receiving 3264 citations. Previous affiliations of Masaru Yamaizumi include Kyoto University.
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Journal ArticleDOI
Rad18 guides polη to replication stalling sites through physical interaction and PCNA monoubiquitination
Kenji Watanabe,Satoshi Tateishi,Michio Kawasuji,Toshiki Tsurimoto,Hirokazu Inoue,Masaru Yamaizumi +5 more
TL;DR: It is shown that polη does not form nuclear foci in RAD18−/− cells after UV irradiation, and Rad18 is crucial for recruitment ofPolη to the damaged site through protein–protein interaction and PCNA monoubiquitination.
Journal Article
U.v.-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle.
Masaru Yamaizumi,T Sugano +1 more
TL;DR: Results strongly suggest that u.v.-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes, which is related to DNA repair capacity.
Journal ArticleDOI
Multiple roles of Rev3, the catalytic subunit of polζ in maintaining genome stability in vertebrates
Eiichiro Sonoda,Takashi Okada,Guang Yu Zhao,Satoshi Tateishi,Kasumi Araki,Masaru Yamaizumi,Takashi Yagi,Nicole S. Verkaik,Dik C. van Gent,Minoru Takata,Shunichi Takeda +10 more
TL;DR: Interestingly, REV3−/− cells showed reduced gene targeting efficiencies and significant increase in the level of chromosomal breaks in the subsequent M phase after IR in the G2 phase, suggesting the involvement of Rev3 in HR‐mediated double‐strand break repair.
Journal ArticleDOI
Rad18 Regulates DNA Polymerase κ and Is Required for Recovery from S-Phase Checkpoint-Mediated Arrest
Xiaohui Bi,Laura R. Barkley,Damien M. Slater,Satoshi Tateishi,Masaru Yamaizumi,Haruo Ohmori,Cyrus Vaziri +6 more
TL;DR: Results indicate that ATR/Chk1 signaling is required for Rad18-mediated PCNA monoubiquitination, and recruitment of Polκ to ubiquitinated PCNA enables lesion bypass and eliminates stalled forks, thereby attenuating the S-phase checkpoint.
Journal ArticleDOI
Human Damage-specific DNA-binding Protein p48 CHARACTERIZATION OF XPE MUTATIONS AND REGULATION FOLLOWING UV IRRADIATION
TL;DR: Results indicate that compound heterozygous mutations in DDB2 (p48) lead to a L350P change from one allele and a Asn-349 deletion from the other and they do not affect nuclear localization of p48, implying that p48 limits DDB activity in vivo.