M
Masatake Hara
Researcher at Kyoto University
Publications - 20
Citations - 2713
Masatake Hara is an academic researcher from Kyoto University. The author has contributed to research in topics: Mast cell & Muscle hypertrophy. The author has an hindex of 14, co-authored 17 publications receiving 2511 citations.
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Journal ArticleDOI
Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice
Hiroyuki Nishimura,Taku Okazaki,Yoshimasa Tanaka,Kazuki Nakatani,Masatake Hara,Akira Matsumori,Shigetake Sasayama,Akira Mizoguchi,Hiroshi Hiai,Nagahiro Minato,Tasuku Honjo +10 more
TL;DR: Results indicate that PD-1 may be an important factor contributing to the prevention of autoimmune diseases and high-titer circulating IgG autoantibodies reactive to a 33-kilodalton protein expressed specifically on the surface of cardiomyocytes.
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Evidence for a role of mast cells in the evolution to congestive heart failure
Masatake Hara,Koh Ono,Myung-Woo Hwang,Atsushi Iwasaki,Masaharu Okada,Kazuki Nakatani,Shigetake Sasayama,Akira Matsumori +7 more
TL;DR: Observations suggest that mast cells play a critical role in the progression of heart failure, and stabilization of mast cells may represent a new approach in the management ofHeart failure.
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Neutralization of interleukin-1β in the acute phase of myocardial infarction promotes the progression of left ventricular remodeling
Myung-Woo Hwang,Akira Matsumori,Yutaka Furukawa,Koh Ono,Masaharu Okada,Atsushi Iwasaki,Masatake Hara,Tadashi Miyamoto,Masanao Touma,Shigetake Sasayama +9 more
TL;DR: Anti–IL-1β treatment suppressed pro-collagen gene expression and delayed wound healing mechanisms—properties that are likely to lead to progression of LV remodeling in the early phase after myocardial infarction.
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Mast cells cause apoptosis of cardiomyocytes and proliferation of other intramyocardial cells in vitro.
Masatake Hara,Akira Matsumori,Koh Ono,Hiroshi Kido,Myung-Woo Hwang,Tadashi Miyamoto,Atsushi Iwasaki,Masaharu Okada,Kazuki Nakatani,Shigetake Sasayama +9 more
TL;DR: The results suggest that mast cell chymase may play a role in the progression of heart failure, because loss of cardiomyocytes and proliferation of nonmyocardial cells exaggerate its pathophysiology.
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FTY720, a New Immunosuppressant, Promotes Long-Term Graft Survival and Inhibits the Progression of Graft Coronary Artery Disease in a Murine Model of Cardiac Transplantation
Myung-Woo Hwang,Akira Matsumori,Yutaka Furukawa,Koh Ono,Masaharu Okada,Atsushi Iwasaki,Masatake Hara,Shigetake Sasayama +7 more
TL;DR: FTY720 promoted long-term cardiac graft survival and strongly inhibited the progression of graft atherosclerosis, suggesting that FTY720 has a promising clinical potential in cardiac transplantation.