K
Kazuki Nakatani
Researcher at Osaka City University
Publications - 50
Citations - 4234
Kazuki Nakatani is an academic researcher from Osaka City University. The author has contributed to research in topics: Hepatic stellate cell & Apoptosis. The author has an hindex of 23, co-authored 50 publications receiving 3957 citations.
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Journal ArticleDOI
Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice
Hiroyuki Nishimura,Taku Okazaki,Yoshimasa Tanaka,Kazuki Nakatani,Masatake Hara,Akira Matsumori,Shigetake Sasayama,Akira Mizoguchi,Hiroshi Hiai,Nagahiro Minato,Tasuku Honjo +10 more
TL;DR: Results indicate that PD-1 may be an important factor contributing to the prevention of autoimmune diseases and high-titer circulating IgG autoantibodies reactive to a 33-kilodalton protein expressed specifically on the surface of cardiomyocytes.
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In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases.
TL;DR: Oxidative cellular damage occurs frequently in livers with NAFLD and may be associated with some clinico-pathological features ofNAFLD including liver fibrosis and possibly, hepatocarcinogenesis.
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Characterization of a Stellate Cell Activation-associated Protein (STAP) with Peroxidase Activity Found in Rat Hepatic Stellate Cells
Norifumi Kawada,Dan Bach Kristensen,Kinji Asahina,Kazuki Nakatani,Yukiko Minamiyama,Shuichi Seki,Katsutoshi Yoshizato +6 more
TL;DR: Results indicate that STAP is a novel endogenous peroxidase catabolizing hydrogen peroxide and lipid hydroperoxides, both of which have been reported to trigger stellate cell activation and consequently promote progression of liver fibrosis and could thus play a role as an antifibrotic scavenger of peroxides in the liver.
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Evidence for a role of mast cells in the evolution to congestive heart failure
Masatake Hara,Koh Ono,Myung-Woo Hwang,Atsushi Iwasaki,Masaharu Okada,Kazuki Nakatani,Shigetake Sasayama,Akira Matsumori +7 more
TL;DR: Observations suggest that mast cells play a critical role in the progression of heart failure, and stabilization of mast cells may represent a new approach in the management ofHeart failure.
Journal ArticleDOI
Cytoglobin/STAP, its unique localization in splanchnic fibroblast-like cells and function in organ fibrogenesis.
Kazuki Nakatani,Hiroaki Okuyama,Yasuyuki Shimahara,Shigeru Saeki,Dong-Ho Kim,Yuji Nakajima,Shuichi Seki,Norifumi Kawada,Katsutoshi Yoshizato +8 more
TL;DR: Results indicate that Cygb/STAP is a tissue globin uniquely localized in splanchnic fibroblastic cell lineage and may play a role in fibrotic organ disorder.