M
Masatoshi Hagiwara
Researcher at Kyoto University
Publications - 286
Citations - 17513
Masatoshi Hagiwara is an academic researcher from Kyoto University. The author has contributed to research in topics: Protein kinase A & RNA splicing. The author has an hindex of 60, co-authored 272 publications receiving 16297 citations. Previous affiliations of Masatoshi Hagiwara include University of Tokyo & Tokyo Medical and Dental University.
Papers
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Journal ArticleDOI
Type-specific expression of protein kinase C isozymes in CNS tumor cells
Sa-i Shimosawa,Takahisa Hachiya,Masatoshi Hagiwara,Nobuteru Usuda,Kenichiro Sugita,Hiroyoshi Hidaka +5 more
TL;DR: Results suggest that PK-C isozymes may be specifically expressed, depending on types of central nervous system (CNS) tumor cells, in cultured human glial and neuronal cell lines.
Journal Article
Overcoming of vinblastine resistance by isoquinolinesulfonamide compounds in adriamycin-resistant leukemia cells.
Shinya Wakusawa,Shigeo Nakamura,K. Tajima,Ken-ichi Miyamoto,Masatoshi Hagiwara,Hiroyoshi Hidaka +5 more
TL;DR: Results indicate that hydrophobic isoquinoline derivatives reverse multidrug resistance due to the suppression of drug binding to P-glycoprotein, without involvement of their activities on protein kinase A andprotein kinase C.
Patent
Method of regulating phosphorylation of sr protein and antiviral agents comprising sr protein activity regulator as the active ingredient
TL;DR: In this article, antiviral agents which are efficacious against a novel virus and widely applicable and show a highly sustained effect are provided to cope with the occurrence of various novel viruses.
Journal ArticleDOI
Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation.
Tomohisa Tanaka,Kaori Okuyama-Dobashi,Shuko Murakami,Wenjia Chen,Toru Okamoto,Keiji Ueda,Takamitsu Hosoya,Yoshiharu Matsuura,Akihide Ryo,Yasuhito Tanaka,Masatoshi Hagiwara,Kohji Moriishi +11 more
TL;DR: The antiviral activity of entecavir was significantly enhanced by the combination with FIT-039 in the chimeric mice having human hepatocytes infected with HBV and none of the mice had significant drug-related body weight or serum human-albumin concentration changes.
Journal ArticleDOI
Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with spliced mRNA.
Naoyuki Kataoka,Michael D. Diem,Mayumi Yoshida,Chihiro Hatai,Izumi Dobashi,Gideon Dreyfuss,Masatoshi Hagiwara,Mutsuhito Ohno +7 more
TL;DR: A 12-amino-acid peptide near Y14's carboxyl terminus is identified that is required for its association with spliced mRNAs, as well as for Magoh binding, suggesting the existence of both the nuclear import pathway and function for Y14 unaccompanied by Magoh.