M
Masaya Nagao
Researcher at Kyoto University
Publications - 104
Citations - 6592
Masaya Nagao is an academic researcher from Kyoto University. The author has contributed to research in topics: Erythropoietin & Erythropoietin receptor. The author has an hindex of 34, co-authored 103 publications receiving 6283 citations.
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Journal ArticleDOI
Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death
TL;DR: It is suggested that erythropoietin plays a neuroprotective role in brain injury caused by hypoxia or ischemia and that eriespheric-induced Ca2+ influx from outside of the cells is a critical initial event yielding an enhanced resistance of the neurons to glutamate toxicity.
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A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes.
TL;DR: The results provide a novel site of Epo production and suggest that Epo acts on neurons in a paracrine fashion, and the regulation of EpO production by oxygen operates at the level of its mRNA.
Journal ArticleDOI
Erythropoietin as a Retinal Angiogenic Factor in Proliferative Diabetic Retinopathy
Daisuke Watanabe,Kiyoshi Suzuma,Shigeyuki Matsui,Masafumi Kurimoto,Junichi Kiryu,Mihori Kita,Izumi Suzuma,Hirokazu Ohashi,Tomonari Ojima,Tomoaki Murakami,Toshihiro Kobayashi,Seiji Masuda,Masaya Nagao,Nagahisa Yoshimura,Hitoshi Takagi +14 more
TL;DR: The data suggest that erythropoietin is a potent ischemia-induced angiogenic factor that acts independently of VEGF during retinal angiogenesis in proliferative diabetic retinopathy.
Journal ArticleDOI
Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells.
Seiji Masuda,Masaya Nagao,Kyoya Takahata,Yoshihiro Konishi,Ferenc Gallyas,Takeshi Tabira,Ryuzo Sasaki +6 more
TL;DR: The binding of Epo to PC12 cells caused a rapid increase in the cytosolic concentration of free calcium, indicating that Epo stimulated the calcium influx from outside of the cells.
Functional Erythropoietin Receptor of the Cells with Neural Characteristics
TL;DR: In this paper, radioiodinated erythropoietin (Epo) was bound specifically to the cells of two non-erythroid clonal lines, PC12 and SN6, which expressed neuronal characteristics.