Massimiliano Stagi

TL;DR: An Aβ oligomer signal transduction pathway that requires PrPC and Fyn to alter synaptic function, with deleterious consequences in Alzheimer's disease is delineated.

TL;DR: Transmembrane PSD proteins heterologously screened for the ability to couple Aβo-PrP(C) with Fyn and found coexpression of the metabotropic glutamate receptor, mGluR5, allowed PrP (C)-bound A βo to activate Fyn.

TL;DR: Intravenous application of TREM2-transduced bone marrow–derived myeloid precursor cells at the EAE peak led to an amelioration of clinical symptoms, reduction in axonal damage, and prevention of further demyelination, indicating a new attractive target for promotion of repair and resolution of inflammation in multiple sclerosis and other neuroinflammatory diseases.

TL;DR: A direct role of CD14 in Abeta(42) phagocytosis is demonstrated, and a pronounced CD14 immunoreactivity on parenchymal microglia spatially correlated to characteristic Alzheimer's disease lesion sites in brain sections of Alzheimer’s disease patients but not inbrain sections of control subjects are detected.

TL;DR: Two immunoglobulin superfamily members, SynCAM 1 and 2, are defined that are expressed in neurons in the developing brain and localize to excitatory and inhibitory synapses and function as components of novel heterophilic transsynaptic adhesion complexes that set up asymmetric interactions.