Maryse Letiembre

TL;DR: It is shown that a spontaneous loss-of-function mutation in the Tlr4 gene strongly inhibits microglial and monocytic activation by aggregated Alzheimer amyloid peptide resulting in a significantly lower release of the inflammatory products IL-6, TNFα and nitric oxide.

TL;DR: A direct role of CD14 in Abeta(42) phagocytosis is demonstrated, and a pronounced CD14 immunoreactivity on parenchymal microglia spatially correlated to characteristic Alzheimer's disease lesion sites in brain sections of Alzheimer’s disease patients but not inbrain sections of control subjects are detected.

TL;DR: A uniform pattern of innate immune response in animal models of neurodegenerative diseases clearly indicates that this response is part of a non-specific neuroinflammatory effector phase rather than a disease-specific event.

TL;DR: Data suggest that plant sterols could have neutral or even protective effects on development of coronary heart disease, which have to be confirmed in interventional trials.

TL;DR: It is concluded that phagocytosis of myelin suppresses microglial inflammatory activities via enhancement of p47-PHOX-mediated ROS generation, and suggests that intervention in ROS generation could represent a novel therapeutic strategy to reduce neuroinflammation in MS.