M
Massimo Primignani
Researcher at University of Milan
Publications - 118
Citations - 6409
Massimo Primignani is an academic researcher from University of Milan. The author has contributed to research in topics: Cirrhosis & Internal medicine. The author has an hindex of 34, co-authored 98 publications receiving 5537 citations. Previous affiliations of Massimo Primignani include Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico.
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Journal ArticleDOI
Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests.
Armando Tripodi,Francesco Salerno,Veena Chantarangkul,Marigrazia Clerici,Massimo Cazzaniga,Massimo Primignani,Pier Mannuccio Mannucci +6 more
TL;DR: In this paper, the authors used a thrombin generation test to investigate the coagulation function in patients with cirrhosis, and they found that the reduction of pro-coagulant factors in patients had little impact on the reduction in anticoagulants.
Journal ArticleDOI
An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis.
Armando Tripodi,Massimo Primignani,Veena Chantarangkul,Alessandra Dell'Era,Marigrazia Clerici,Roberto de Franchis,Massimo Colombo,Pier Mannuccio Mannucci +7 more
TL;DR: The hypercoagulability of plasma from patients with cirrhosis appears to result from increased levels of factor VIII and decreased levels of protein C-typical features of patients with Cirrhosis, which might explain the risk for venous thromboembolism in patients with chronic liver disease.
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Acute portal vein thrombosis unrelated to cirrhosis: a prospective multicenter follow-up study.
Aurélie Plessier,Sarwa S. Darwish-Murad,Manuel Hernández-Guerra,Yann Consigny,Federica F. Fabris,Jonel Trebicka,Jörg Heller,Isabelle Morard,L Lasser,Philippe Langlet,Marie-Hélène Denninger,Dominique Vidaud,Bertrand Condat,Antoine Hadengue,Massimo Primignani,Juan Carlos García-Pagán,Harry L.A. Janssen,Dominique Valla +17 more
TL;DR: Recanalization occurs in one‐third of patients receiving early anticoagulation for acute portal vein thrombosis, whereas thrombus extension, intestinal infarction, severe bleeding, and death are rare, and alternative therapy should be considered when ascites and splenic vein obstruction are present.
Journal ArticleDOI
Natural history of portal hypertension in patients with cirrhosis.
TL;DR: All patients with cirrhosis will eventually develop portal hypertension and esophagogastric varices, and patients surviving a variceal hemorrhage must be treated to prevent rebleeding.
Journal ArticleDOI
Thrombin generation in patients with cirrhosis: The role of platelets†
Armando Tripodi,Massimo Primignani,Veena Chantarangkul,Marigrazia Clerici,Alessandra Dell'Era,Federica Fabris,Francesco Salerno,Pier Mannuccio Mannucci +7 more
TL;DR: Severe thrombocytopenia may limit thrombin generation in patients with cirrhosis, and these findings might justify platelet transfusion in Patients with low platelet counts when they bleed spontaneously or before undergoing surgery or liver biopsy.