P
Pier Mannuccio Mannucci
Researcher at Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Publications - 817
Citations - 52759
Pier Mannuccio Mannucci is an academic researcher from Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico. The author has contributed to research in topics: Von Willebrand factor & Von Willebrand disease. The author has an hindex of 110, co-authored 777 publications receiving 48578 citations. Previous affiliations of Pier Mannuccio Mannucci include Harvard University & University of Milan.
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Journal ArticleDOI
Plasma HDL cholesterol and risk of myocardial infarction: A mendelian randomisation study
Benjamin F. Voight,Benjamin F. Voight,Benjamin F. Voight,Gina M. Peloso,Gina M. Peloso,Marju Orho-Melander,Ruth Frikke-Schmidt,Maja Barbalić,Majken K. Jensen,George Hindy,Hilma Holm,Eric L. Ding,Toby Johnson,Heribert Schunkert,Nilesh J. Samani,Nilesh J. Samani,Robert Clarke,Jemma C. Hopewell,John F. Thompson,Mingyao Li,Gudmar Thorleifsson,Christopher Newton-Cheh,Kiran Musunuru,Kiran Musunuru,James P. Pirruccello,James P. Pirruccello,Danish Saleheen,Li Chen,Alexandre F.R. Stewart,Arne Schillert,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Gudmundur Thorgeirsson,Sonia S. Anand,James C. Engert,Thomas M. Morgan,John A. Spertus,Monika Stoll,Klaus Berger,Nicola Martinelli,Domenico Girelli,Pascal P. McKeown,Christopher Patterson,Stephen E. Epstein,Joseph M. Devaney,Mary Susan Burnett,Vincent Mooser,Samuli Ripatti,Ida Surakka,Markku S. Nieminen,Juha Sinisalo,Marja-Liisa Lokki,Markus Perola,Aki S. Havulinna,Ulf de Faire,Bruna Gigante,Erik Ingelsson,Tanja Zeller,Philipp S. Wild,Paul I.W. de Bakker,Olaf H. Klungel,Anke-Hilse Maitland-van der Zee,Bas J M Peters,Anthonius de Boer,Diederick E. Grobbee,Pieter Willem Kamphuisen,Vera H.M. Deneer,Clara C. Elbers,N. Charlotte Onland-Moret,Marten H. Hofker,Cisca Wijmenga,W. M. Monique Verschuren,Jolanda M. A. Boer,Yvonne T. van der Schouw,Asif Rasheed,Philippe M. Frossard,Serkalem Demissie,Serkalem Demissie,Cristen J. Willer,Ron Do,Jose M. Ordovas,Jose M. Ordovas,Gonçalo R. Abecasis,Michael Boehnke,Karen L. Mohlke,Mark J. Daly,Mark J. Daly,Candace Guiducci,Noël P. Burtt,Aarti Surti,Elena Gonzalez,Shaun Purcell,Shaun Purcell,Stacey Gabriel,Jaume Marrugat,John F. Peden,Jeanette Erdmann,Patrick Diemert,Christina Willenborg,Inke R. König,Marcus Fischer,Christian Hengstenberg,Andreas Ziegler,Ian Buysschaert,Diether Lambrechts,Frans Van de Werf,Keith A.A. Fox,Nour Eddine El Mokhtari,Diana Rubin,Jürgen Schrezenmeir,Stefan Schreiber,Arne Schäfer,John Danesh,Stefan Blankenberg,Robert Roberts,Ruth McPherson,Hugh Watkins,Alistair S. Hall,Kim Overvad,Eric B. Rimm,Eric Boerwinkle,Anne Tybjærg-Hansen,L. Adrienne Cupples,L. Adrienne Cupples,Muredach P. Reilly,Olle Melander,Pier Mannuccio Mannucci,Diego Ardissino,David S. Siscovick,Roberto Elosua,Kari Stefansson,Kari Stefansson,Christopher J. O'Donnell,Christopher J. O'Donnell,Veikko Salomaa,Daniel J. Rader,Leena Peltonen,Leena Peltonen,Stephen M. Schwartz,David Altshuler,Sekar Kathiresan +140 more
TL;DR: In this paper, a Mendelian randomisation analysis was performed to compare the effect of HDL cholesterol, LDL cholesterol, and genetic score on risk of myocardial infarction.
Journal ArticleDOI
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Heribert Schunkert,Inke R. König,Sekar Kathiresan,Muredach P. Reilly,Themistocles L. Assimes,Hilma Holm,Michael Preuss,Alexandre F.R. Stewart,Maja Barbalić,Christian Gieger,Devin Absher,Zouhair Aherrahrou,Hooman Allayee,David Altshuler,Sonia S. Anand,Karl Andersen,Jeffrey L. Anderson,Diego Ardissino,Stephen G. Ball,Anthony J. Balmforth,Timothy A. Barnes,Diane M. Becker,Lewis C. Becker,Klaus Berger,Joshua C. Bis,S. Matthijs Boekholdt,Eric Boerwinkle,Peter S. Braund,Morris J. Brown,Mary Susan Burnett,Ian Buysschaert,John F. Carlquist,Li Chen,Sven Cichon,Veryan Codd,Robert W. Davies,George Dedoussis,Abbas Dehghan,Serkalem Demissie,Joseph M. Devaney,Patrick Diemert,Ron Do,Angela Doering,Sandra Eifert,Nour Eddine El Mokhtari,Stephen G. Ellis,Roberto Elosua,James C. Engert,Stephen E. Epstein,Ulf de Faire,Marcus Fischer,Aaron R. Folsom,Jennifer Freyer,Bruna Gigante,Domenico Girelli,Solveig Gretarsdottir,Vilmundur Gudnason,Jeffrey R. Gulcher,Eran Halperin,Naomi Hammond,Stanley L. Hazen,Albert Hofman,Benjamin D. Horne,Thomas Illig,Carlos Iribarren,Gregory T. Jones,J. Wouter Jukema,Michael A. Kaiser,Lee M. Kaplan,John J.P. Kastelein,Kay-Tee Khaw,Joshua W. Knowles,G. Kolovou,Augustine Kong,Reijo Laaksonen,Diether Lambrechts,Karin Leander,Guillaume Lettre,Mingyao Li,Wolfgang Lieb,Christina Loley,Andrew J. Lotery,Pier Mannuccio Mannucci,Seraya Maouche,Nicola Martinelli,Pascal P. McKeown,Christa Meisinger,Thomas Meitinger,Olle Melander,Pier Angelica Merlini,Vincent Mooser,Thomas M. Morgan,Thomas W. Mühleisen,Joseph B. Muhlestein,Thomas Münzel,Kiran Musunuru,Janja Nahrstaedt,Christopher P. Nelson,Markus M. Nöthen,Oliviero Olivieri,Riyaz S. Patel,Christopher Patterson,Annette Peters,Flora Peyvandi,Liming Qu,Arshed A. Quyyumi,Daniel J. Rader,Loukianos S. Rallidis,Catherine M. Rice,Frits R. Rosendaal,Diana Rubin,Veikko Salomaa,M. Lourdes Sampietro,M. S. Sandhu,Eric E. Schadt,Arne Scḧsignfer,Arne Schillert,Stefan Schreiber,Jürgen Schrezenmeir,Stephen M. Schwartz,David S. Siscovick,Mohan U. Sivananthan,Suthesh Sivapalaratnam,Albert V. Smith,Tamara B. Smith,Jaapjan D. Snoep,Nicole Soranzo,John A. Spertus,Klaus Stark,Kathy Stirrups,Monika Stoll,W.H. Wilson Tang,Stephanie Tennstedt,Gudmundur Thorgeirsson,Gudmar Thorleifsson,Maciej Tomaszewski,André G. Uitterlinden,Andre M. van Rij,Benjamin F. Voight,Nicholas J. Wareham,George A. Wells,H.-Erich Wichmann,Philipp S. Wild,Christina Willenborg,Jaqueline C M Witteman,Benjamin J. Wright,Shu Ye,Tanja Zeller,Andreas Ziegler,François Cambien,Alison H. Goodall,L. Adrienne Cupples,Thomas Quertermous,Winfried Mäsignrz,Christian Hengstenberg,Stefan Blankenberg,Willem H. Ouwehand,Alistair S. Hall,Panos Deloukas,John R. Thompson,Kari Stefansson,Robert Roberts,Unnur Thorsteinsdottir,Christopher J. O'Donnell,Ruth McPherson,Jeanette Erdmann,Nilesh J. Samani +166 more
TL;DR: This paper performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals.
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
Benjamin F. Voight,Gina M. Peloso,Marju Orho-Melander,Ruth Frikke-Schmidt,Maja Barbalić,Majken K. Jensen,George Hindy,Hilma Holm,Eric L. Ding,Toby Johnson,Heribert Schunkert,Nilesh J. Samani,Robert Clarke,Jemma C. Hopewell,John F. Thompson,Mingyao Li,Gudmar Thorleifsson,Christopher Newton-Cheh,Kiran Musunuru,James P. Pirruccello,Danish Saleheen,Li Chen,Alexandre F.R. Stewart,Arne Schillert,Unnur Thorsteinsdottir,Gudmundur Thorgeirsson,Sonia S. Anand,James C. Engert,Thomas M. Morgan,John A. Spertus,Monika Stoll,Klaus Berger,Nicola Martinelli,Domenico Girelli,Pascal P. McKeown,Christopher Patterson,Stephen E. Epstein,Joseph M. Devaney,Mary-Susan Burnett,Vincent Mooser,Samuli Ripatti,Ida Surakka,Markku S. Nieminen,Juha Sinisalo,Marja-Liisa Lokki,Markus Perola,Aki S. Havulinna,Ulf de Faire,Bruna Gigante,Erik Ingelsson,Tanja Zeller,Philipp S. Wild,Paul I.W. de Bakker,Olaf H. Klungel,Anke-Hilse Maitland-van der Zee,Bas J M Peters,Anthonius de Boer,Diederick E. Grobbee,Pieter Willem Kamphuisen,Vera H.M. Deneer,Clara C. Elbers,N. Charlotte Onland-Moret,Marten H. Hofker,Cisca Wijmenga,W. M. Monique Verschuren,Jolanda M. A. Boer,Yvonne T. van der Schouw,Asif Rasheed,Philippe M. Frossard,Serkalem Demissie,Cristen J. Willer,Ron Do,Jose M. Ordovas,Gonçalo R. Abecasis,Michael Boehnke,Karen L. Mohlke,Mark J. Daly,Candace Guiducci,Noël P. Burtt,Aarti Surti,Elena Gonzalez,Shaun Purcell,Stacey Gabriel,Jaume Marrugat,John F. Peden,Jeanette Erdmann,Patrick Diemert,Christina Willenborg,Inke R. Koenig,Marcus Fischer,Christian Hengstenberg,Andreas Ziegler,Ian Buysschaert,Diether Lambrechts,Frans Van de Werf,Keith A.A. Fox,Nour Eddine El Mokhtari,Diana Rubin,Juergen Schrezenmeir,Stefan Schreiber,Arne S. Schaefer,John Danesh,Stefan Blankenberg,Robert Roberts,Ruth McPherson,Hugh Watkins,Alistair S. Hall,Kim Overvad,Eric B. Rimm,Eric Boerwinkle,Anne Tybjærg-Hansen,L. Adrienne Cupples,Muredach P. Reilly,Olle Melander,Pier Mannuccio Mannucci,Diego Ardissino,David S. Siscovick,Roberto Elosua,Kari Stefansson,Christopher J. O'Donnell,Veikko Salomaa,Daniel J. Rader,Leena Peltonen,Stephen M. Schwartz,David Altshuler,Sekar Kathiresan +125 more
TL;DR: Mendelian randomisation analyses challenge the concept that raising of plasma HDL cholesterol will uniformly translate into reductions in risk of myocardial infarction.
Journal ArticleDOI
Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Helena Furberg,Yunjung Kim,Jennifer Dackor,Eric Boerwinkle,Nora Franceschini,Diego Ardissino,Luisa Bernardinelli,Luisa Bernardinelli,Pier Mannuccio Mannucci,Francesco Mauri,Piera Angelica Merlini,Devin Absher,Themistocles L. Assimes,Stephen P. Fortmann,Carlos Iribarren,Joshua W. Knowles,Thomas Quertermous,Luigi Ferrucci,Toshiko Tanaka,Joshua C. Bis,Curt D. Furberg,Talin Haritunians,Barbara McKnight,Bruce M. Psaty,Bruce M. Psaty,Kent D. Taylor,Evan L. Thacker,Peter Almgren,Leif Groop,Claes Ladenvall,Michael Boehnke,Anne U. Jackson,Karen L. Mohlke,Heather M. Stringham,Jaakko Tuomilehto,Jaakko Tuomilehto,Emelia J. Benjamin,Shih-Jen Hwang,Daniel Levy,Sarah R. Preis,Ramachandran S. Vasan,Jubao Duan,Pablo V. Gejman,Douglas F. Levinson,Alan R. Sanders,Jianxin Shi,Esther H. Lips,James McKay,Antonio Agudo,Luigi Barzan,Vladimir Bencko,Simone Benhamou,Simone Benhamou,Xavier Castellsagué,Cristina Canova,David I. Conway,Eleonora Fabianova,Lenka Foretova,Vladimir Janout,Claire M. Healy,Ivana Holcatova,Kristina Kjærheim,Pagona Lagiou,Jolanta Lissowska,Ray Lowry,Tatiana V. Macfarlane,Dana Mates,Lorenzo Richiardi,Peter Rudnai,Neonilia Szeszenia-Dabrowska,David Zaridze,Ariana Znaor,Mark Lathrop,Paul Brennan,Stefania Bandinelli,Timothy M. Frayling,Jack M. Guralnik,Yuri Milaneschi,John R. B. Perry,David Altshuler,David Altshuler,Roberto Elosua,S. Kathiresan,S. Kathiresan,Gavin Lucas,Olle Melander,Christopher J. O'Donnell,Veikko Salomaa,Stephen M. Schwartz,Benjamin F. Voight,Brenda W.J.H. Penninx,Johannes H. Smit,Nicole Vogelzangs,Dorret I. Boomsma,Eco J. C. de Geus,Jacqueline M. Vink,Gonneke Willemsen,Stephen J. Chanock,Fangyi Gu,Susan E. Hankinson,David J. Hunter,Albert Hofman,Henning Tiemeier,André G. Uitterlinden,Cornelia M. van Duijn,Stefan Walter,Daniel I. Chasman,Brendan M. Everett,Guillaume Paré,Paul M. Ridker,Ming D. Li,Hermine H. Maes,Janet Audrain-McGovern,Danielle Posthuma,Laura M. Thornton,Caryn Lerman,Jaakko Kaprio,Jaakko Kaprio,Jed E. Rose,John P. A. Ioannidis,John P. A. Ioannidis,Peter Kraft,Danyu Lin,Patrick F. Sullivan +123 more
TL;DR: A meta-analyses of several smoking phenotypes within cohorts of the Tobacco and Genetics Consortium found the strongest association was a synonymous 15q25 SNP in the nicotinic receptor gene CHRNA3, and three loci associated with number of cigarettes smoked per day were identified.
Journal ArticleDOI
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
Sekar Kathiresan,Benjamin F. Voight,Shaun Purcell,Kiran Musunuru,Diego Ardissino,Pier Mannuccio Mannucci,Sonia S. Anand,James C. Engert,Nilesh J. Samani,Heribert Schunkert,Jeanette Erdmann,Muredach P. Reilly,Daniel J. Rader,Thomas M. Morgan,John A. Spertus,Monika Stoll,Domenico Girelli,Pascal P. McKeown,Christopher Patterson,David S. Siscovick,Christopher J. O'Donnell,Roberto Elosua,Leena Peltonen,Veikko Salomaa,Stephen M. Schwartz,Olle Melander,David Altshuler,Pier Angelica Merlini,Carlo Berzuini,Luisa Bernardinelli,Flora Peyvandi,Marco Tubaro,Patrizia Celli,Maurizio Ferrario,Raffaela Fetiveau,Nicola Marziliano,Giorgio Casari,Michele Galli,Flavio Ribichini,Marco Rossi,Francesco Bernardi,Pietro Zonzin,Alberto Piazza,Jean Yee,Yechiel Friedlander,Jaume Marrugat,Gavin Lucas,Isaac Subirana,Joan Sala,Rafael Ramos,James B. Meigs,Gordon H. Williams,David M. Nathan,Calum A. MacRae,Aki S. Havulinna,Göran Berglund,Joel N. Hirschhorn,Rosanna Asselta,Stefano Duga,Marta Spreafico,Mark J. Daly,James Nemesh,Joshua M. Korn,Steven A. McCarroll,Aarti Surti,Candace Guiducci,Lauren Gianniny,Daniel B. Mirel,Melissa Parkin,Noël P. Burtt,Stacey Gabriel,John R. Thompson,Peter S. Braund,Benjamin J. Wright,Anthony J. Balmforth,Stephen G. Ball,Alistair S. Hall,Patrick Linsel-Nitschke,Wolfgang Lieb,Andreas Ziegler,Inke R. König,Christian Hengstenberg,Marcus Fischer,Klaus Stark,Anika Grosshennig,Michael Preuss,H-Erich Wichmann,Stefan Schreiber,Willem H. Ouwehand,Panos Deloukas,Michael Scholz,François Cambien,Mingyao Li,Zhen Chen,Robert L. Wilensky,William H. Matthai,Atif Qasim,Hakon Hakonarson,Joe Devaney,Mary-Susan Burnett,Augusto D. Pichard,Kenneth M. Kent,Lowell F. Satler,Joseph M. Lindsay,Ron Waksman,Stephen E. Epstein,Thomas Scheffold,Klaus Berger,Andreas Huge,Nicola Martinelli,Oliviero Olivieri,Roberto Corrocher,Hilma Holm,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Kari Stefansson,Ron Do,Changchun Xie,David S. Siscovick +118 more
TL;DR: SNPs at nine loci were reproducibly associated with myocardial infarction, but tests of common and rare CNVs failed to identify additional associations with my Cardiovascular Infarction risk.