M
Matan Nachliely
Researcher at Ben-Gurion University of the Negev
Publications - 6
Citations - 110
Matan Nachliely is an academic researcher from Ben-Gurion University of the Negev. The author has contributed to research in topics: Myeloid leukemia & Cellular differentiation. The author has an hindex of 5, co-authored 6 publications receiving 84 citations.
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Journal ArticleDOI
Cancer-selective cytotoxic Ca2+ overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid.
Stella Pesakhov,Matan Nachliely,Zeev Barvish,Nasma Aqaqe,Nasma Aqaqe,Bar Schwartzman,Elena Voronov,Yoav Sharoni,George P. Studzinski,Daniel Fishman,Michael Danilenko +10 more
TL;DR: It is shown that apoptotic response of AML cells to the synergistically acting polyphenols curcumin (CUR) and carnosic acid (CA), combined at low, non-cytotoxic doses of each compound was mediated solely by disruption of cellular Ca2+ homeostasis.
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Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a xenograft mouse model.
Matan Nachliely,Aviram Trachtenberg,Boris Khalfin,Karen Nalbandyan,Merav Cohen-Lahav,Kaori Yasuda,Toshiyuki Sakaki,Andrzej Kutner,Michael Danilenko +8 more
TL;DR: It is demonstrated that in AML cell cultures, moderate pro-differentiation effects of low concentrations of VDDs can be synergistically enhanced by structurally distinct compounds known to activate the transcription factor Nuclear Factor (Erythroid-derived 2)-Like 2 (NFE2L2 or Nrf2) and that co-administration of PRI-5202 and DMF resulted in a marked cooperative inhibition of human AML tumor growth without inducing treatment toxicity.
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Novel analogs of 1,25-dihydroxyvitamin D2 combined with a plant polyphenol as highly efficient inducers of differentiation in human acute myeloid leukemia cells.
TL;DR: The results demonstrate that the new double-point modified 1,25-dihydroxyvitamin D2 analogs are much stronger inducers of myeloid differentiation than 1, 25(OH)2D3 and that their efficacy can be further enhanced by combination with plant polyphenols.
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Prodifferentiation Activity of Novel Vitamin D2 Analogs PRI-1916 and PRI-1917 and Their Combinations with a Plant Polyphenol in Acute Myeloid Leukemia Cells
TL;DR: Results indicate that the 24Z modification has contrasting effects on the differentiation ability of PRi-1906 and PRI-1907 and that the addition of a plant polyphenol could result in a similar extent of cell differentiation induced by different vitamin D compounds.
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Participation of vitamin D-upregulated protein 1 (TXNIP)-ASK1-JNK1 signalosome in the enhancement of AML cell death by a post-cytotoxic differentiation regimen.
TL;DR: It is demonstrated that TXNIP, previously known as Vitamin D up-regulated protein 1 (VDUP1) [PMID 808674] plays a part in signaling cell death (CD) in this regimen, and it is shown that direct activation of ASK1 kinase byTXNIP is required for the optimal transmission of the CD signal to apoptotic machinery, regulated by JNK and BIM.