Showing papers in "The Journal of Steroid Biochemistry and Molecular Biology in 2019"

TL;DR: In this article, an overview of steroid hormone biosynthesis and metabolism by the liver and peripheral tissues is presented, specifically highlighting the pathways linking and differentiating the serum and urine steroid metabolomes.

TL;DR: A broad perspective is given on the relationship between hypercholesterolemia and AD, cholesterol lowering therapies for AD patients and the role of oxysterols in pathological and non-pathological conditions, and proposes cholesterol metabolites as valuable targets for prevention and alternative AD treatments.

TL;DR: With advances in LC/MS/MS and its increased availability, and with the help of studies with recombinant vitamin D-metabolizing enzymes, many other vitamin D metabolites have now been detected and in some cases quantitated, in human serum, some contributing to a more detailed understanding of vitamin D status in health and disease.

TL;DR: Calcitriol has an array of potential protective effects against CRC by acting on carcinoma cells, CAFs, immune cells and probably also the gut microbiota.

TL;DR: This review is aimed at providing an overview of the current knowledge in relation to the regulation of estrogens in adipose tissue and their role in driving breast tumor development, growth and progression.

TL;DR: The role of estrogen in the skeletal muscle is reviewed, outlining the proposed molecular mechanisms and focusing on the current understanding of estrogen actions on mitochondria metabolism in skeletal muscle.

TL;DR: It is shown that alterations in the bioenergetic metabolism of immune cells are central to the immunomodulatory effects induced by 1α,25(OH)2D3, and glycolytic enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 activity is essential for glucose metabolism.

TL;DR: How optimal magnesium and vitamin D balance improve health outcomes in the elderly, the role of magnesium and Vitamin D on bone formation, and the implications of widespread deficiency of these factors in the United States and worldwide are summarized.

TL;DR: Calculated free testosterone may offer the best way forward but better equations are needed to improve accuracy and these should be derived from detailed knowledge of testosterone binding to SHBG.

TL;DR: Long-term supplementation with vitamin D3 in doses ranging from 5000 to 50,000 IUs/day appears to be safe, and three patients with psoriasis showed marked clinical improvement in their skin using 20,000 to 50-000 I Us/day.

TL;DR: Experiments suggest possible mechanisms by which vitamin D may enhance resistance to rhinovirus infection and reduce risk of secondary bacterial infection in vitamin D-deficient individuals.

TL;DR: The reference intervals of the nine steroid hormones by sex, age, and pubertal stage can be further adopted in other laboratories equipped with LC-MS/MS, once the validation with a small number of reference samples is performed.

TL;DR: It is indicated that vitamin D and omega-3 LCPUFA reduced irritability symptoms in children with ASD and vitamin D also reduced hyperactivity symptoms in these children.

TL;DR: Profiling estrogens and their metabolites by mass spectrometry (MS) offers insights into health and disease and improvements in recovery, ion suppression and detection are discussed.

TL;DR: It is demonstrated that under in vivo conditions changes in 25-hydroxyvitamin D3 and 1-25(OH)2D3 serum concentrations alter the expression of more than 700 vitamin D target genes in human leukocytes.

TL;DR: It is suggested that Res and its combination with AR and CXCR4 antagonists can be used in order to suppress the metastatic behaviors of prostate cancer.

TL;DR: It is increasingly becoming apparent in this quickly evolving field that EDC directly affect mESR and estrogen signaling, but such chemicals can also affect proportion of ESR reaching the membrane.

TL;DR: The nanoemulsion (NE-20) fabricated with 30% Kolliphor, 20% CCTG and 50% aqueous phase was found to be the most suitable with respected to zeta potential, emulsion stability and encapsulation efficiency and also demonstrated high bioavailability of vitamin D as compared to other combinations and hence was selected for further physiochemical studies.

TL;DR: The insights of stress-induced adrenal plasticity gained from various experimental models are summarized and their relevance to clinical observations are discussed.

TL;DR: In this paper, the authors quantitatively characterize the mechanisms by which T glucuronide metabolites are eliminated from liver, intestine, and kidney utilizing relative expression factor (this paper) approach.

TL;DR: An understanding of the efflux pathways, their regulation and cross-talk with signaling molecules may provide novel prognostic markers and therapeutic targets to combat the onset of carcinogenesis.

TL;DR: In contrast to fish, serum 11KT concentrations were similar in male and female primates for each species, suggesting that 11KT production in these species is not testis-dependent and primarily originates from adrenal-derived 11-oxyandrogen precursors.

TL;DR: A multidisciplinary approach applying knowledge from engineering, skin photobiology, nutrition, town planning and social science is required to prevent vitamin D deficiency in urban areas, and advice to ethnic minority groups to increase sun exposure, take vitamin D supplements and/or increase consumption of vitamin D rich foods in a way that is safe and culturally acceptable is proposed.

TL;DR: The current review summarizes the dose-dependent in vitro and in vivo interactions of resveratrol and other dietary polyphenols with estrogen precursors, active estrogens, catechol estrogens and their respective glucuronidated, sulfated, glutathionated or O-methylated metabolites in estrogen receptor alpha negative and positive breast cancer.

TL;DR: It is demonstrated that the exposure to CPF promotes mammary tumors development with a reduced steroid receptors expression, and it has also been found that CPF affects HDAC1 mRNA levels in mammary tissue pointing thatCPF may act as a breast cancer risk factor.

TL;DR: Evidence is shown that the androgen receptor contributes to the reprogramming of specific cellular metabolic pathways that promote tumor growth and disease progression, including aerobic glycolysis, mitochondrial respiration, fatty acid ß-oxidation, and de novo lipid synthesis.

TL;DR: Dysfunctions in the metabolism of glycerolipid, glycerophospholips, sphingolipids, and glycosphingolIPid biosynthesis in PCOS patients' follicles play a non-ignorable role in declining the 2 pronuclei fertilization rate during IVF procedure.

TL;DR: One year or longer supplementation with a large daily, weekly or monthly dose of vitamin D2 /D3 did not significantly increase a risk of total adverse events or kidney stones, although there was a trend towards increased hypercalcemia, and possibly for hypercalciuria.

TL;DR: Isoflavones increased T3 availability in the liver of MA males, despite decreasing serum T4, and failed to induce any hypocholesterolemic effect.

TL;DR: This study showed that expression of visfatin protein is steroid dependent in mouse uterus which is involved in the regulation of proliferation and apoptosis via modulating antioxidant system in the uterus of mice during the reproductive cycle.