M
Mathilde Body-Malapel
Researcher at university of lille
Publications - 44
Citations - 5833
Mathilde Body-Malapel is an academic researcher from university of lille. The author has contributed to research in topics: Inflammation & Colitis. The author has an hindex of 24, co-authored 39 publications receiving 5109 citations. Previous affiliations of Mathilde Body-Malapel include University of Michigan & French Institute of Health and Medical Research.
Papers
More filters
Journal ArticleDOI
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages
Luigi Franchi,Amal O. Amer,Mathilde Body-Malapel,Thirumala-Devi Kanneganti,Nesrin Özören,Rajesh Jagirdar,Naohiro Inohara,Peter Vandenabeele,John Bertin,Anthony J. Coyle,Anthony J. Coyle,Ethan P. Grant,Gabriel Núñez +12 more
TL;DR: The authors showed that salmonella-infected and lipopolysaccharide-tolerant macrophages were deficient in activation of caspase-1 and in interleukin 1beta secretion, although transcription factor NF-kappaB-dependent production of the chemokine MCP-1 was unimpaired.
Journal ArticleDOI
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
Thirumala-Devi Kanneganti,Nesrin Özören,Mathilde Body-Malapel,Amal O. Amer,Jong Hwan Park,Luigi Franchi,Joel Whitfield,Winfried Barchet,Marco Colonna,Peter Vandenabeele,John Bertin,Anthony J. Coyle,Anthony J. Coyle,Ethan P. Grant,Shizuo Akira,Gabriel Núñez +15 more
TL;DR: A critical role for cryopyrin in host defence through bacterial RNA-mediated activation of caspase-1 is revealed and insights regarding the pathogenesis of autoinflammatory syndromes are provided.
Journal ArticleDOI
Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA
Thirumala-Devi Kanneganti,Mathilde Body-Malapel,Amal O. Amer,Jong Hwan Park,Joel Whitfield,Luigi Franchi,Zenobia F. Taraporewala,David Miller,John T. Patton,Naohiro Inohara,Gabriel Núñez +10 more
TL;DR: A signaling pathway leading to caspase-1 activation that is induced by double-stranded RNA (dsRNA) and viral infection that is mediated by Cryopyrin/Nalp3 is identified and shown that infection with Sendai and influenza viruses activates the cryopyrIn inflammasome.
Journal ArticleDOI
RICK/RIP2 Mediates Innate Immune Responses Induced through Nod1 and Nod2 but Not TLRs
Jong Hwan Park,Yun Gi Kim,Christine McDonald,Thirumala-Devi Kanneganti,Mizuho Hasegawa,Mathilde Body-Malapel,Naohiro Inohara,Gabriel Núñez +7 more
TL;DR: It is shown that macrophages and mice lacking RICK are defective in their responses to Nod1 and Nod2 agonists but exhibit unimpaired responses to synthetic and highly purified TLR agonists.
Journal ArticleDOI
Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf.
Amal O. Amer,Luigi Franchi,Thirumala-Devi Kanneganti,Mathilde Body-Malapel,Nesrin Özören,Graham F. Brady,Sasha Meshinchi,Rajesh Jagirdar,Andrew T. Gewirtz,Shizuo Akira,Gabriel Núñez +10 more
TL;DR: It is demonstrated that the presence of flagellin and a competent type IV secretion system are critical for Legionella to activate caspase-1 in macrophages, providing a novel function for NLR proteins in host defense against an intracellular bacterium.