M
Mizuho Hasegawa
Researcher at University of Michigan
Publications - 35
Citations - 3263
Mizuho Hasegawa is an academic researcher from University of Michigan. The author has contributed to research in topics: NOD1 & Peptidoglycan. The author has an hindex of 22, co-authored 35 publications receiving 2913 citations. Previous affiliations of Mizuho Hasegawa include Kanazawa University & Shinshu University.
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Journal ArticleDOI
RICK/RIP2 Mediates Innate Immune Responses Induced through Nod1 and Nod2 but Not TLRs
Jong Hwan Park,Yun Gi Kim,Christine McDonald,Thirumala-Devi Kanneganti,Mizuho Hasegawa,Mathilde Body-Malapel,Naohiro Inohara,Gabriel Núñez +7 more
TL;DR: It is shown that macrophages and mice lacking RICK are defective in their responses to Nod1 and Nod2 agonists but exhibit unimpaired responses to synthetic and highly purified TLR agonists.
Journal ArticleDOI
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-κB activation
Mizuho Hasegawa,Yukari Fujimoto,Peter C. Lucas,Hiroyasu Nakano,Koichi Fukase,Gabriel Núñez,Naohiro Inohara,Naohiro Inohara +7 more
TL;DR: RICK polyubiquitination links TAK1 to IKK complexes, a critical step in Nod1/Nod2‐mediated NF‐κB activation, and is shown to be essential for RICK‐mediated IKK activation and cytokine/chemokine secretion.
Journal ArticleDOI
Staphylococcus δ-toxin induces allergic skin disease by activating mast cells
Yuumi Nakamura,Jon Oscherwitz,Kemp B. Cease,Susana M. Chan,Raúl Muñoz-Planillo,Mizuho Hasegawa,Amer E. Villaruz,Gordon Y. C. Cheung,Martin J. McGavin,Jeffrey B. Travers,Michael Otto,Naohiro Inohara,Gabriel Núñez +12 more
TL;DR: In this article, the role of staphylococcal exotoxins in disease pathogenesis remains unclear, however, the authors identify δ-toxin as a potent inducer of mast cell degranulation and suggest a mechanistic link between S. aureus colonization and allergic skin disease.
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Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury
Sang Uk Seo,Nobuhiko Kamada,Raúl Muñoz-Planillo,Yun Gi Kim,Dae Yong Kim,Yukiko Koizumi,Mizuho Hasegawa,Stephanie D. Himpsl,Hilary P. Browne,Trevor D. Lawley,Harry L. T. Mobley,Naohiro Inohara,Gabriel Núñez +12 more
TL;DR: It is found that the microbiota induces interleukin-1 β (IL-1β) release upon intestinal injury and that this is mediated via the NLRP3 inflammasome, which promotes inflammation in the intestine.
Journal ArticleDOI
Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo.
Junya Masumoto,Kangkang Yang,Sooryanarayana Varambally,Mizuho Hasegawa,Scott A. Tomlins,Su Qiu,Yukari Fujimoto,Akiko Kawasaki,Simon J. Foster,Yasuo Horie,Tak W. Mak,Gabriel Núñez,Arul M. Chinnaiyan,Koichi Fukase,Naohiro Inohara +14 more
TL;DR: Results indicate that Nod1 functions as a pathogen recognition molecule to induce expression of molecules involved in the early stages of the innate immune response.