There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

Probability Distributions.- Linear Models for Regression.- Linear Models for Classification.- Neural Networks.- Kernel Methods.- Sparse Kernel Machines.- Graphical Models.- Mixture Models and EM.- Approximate Inference.- Sampling Methods.- Continuous Latent Variables.- Sequential Data.- Combining Models.

Pattern Recognition and Machine Learning

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Convex Analysisの二,三の進展について

On robust estimation of the location parameter

Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central sensitization. Central sensitization manifests as pain hypersensitivity, particularly dynamic tactile allodynia, secondary punctate or pressure hyperalgesia, aftersensations, and enhanced temporal summation. It can be readily and rapidly elicited in human volunteers by diverse experimental noxious conditioning stimuli to skin, muscles or viscera, and in addition to producing pain hypersensitivity, results in secondary changes in brain activity that can be detected by electrophysiological or imaging techniques. Studies in clinical cohorts reveal changes in pain sensitivity that have been interpreted as revealing an important contribution of central sensitization to the pain phenotype in patients with fibromyalgia, osteoarthritis, musculoskeletal disorders with generalized pain hypersensitivity, headache, temporomandibular joint disorders, dental pain, neuropathic pain, visceral pain hypersensitivity disorders and post-surgical pain. The comorbidity of those pain hypersensitivity syndromes that present in the absence of inflammation or a neural lesion, their similar pattern of clinical presentation and response to centrally acting analgesics, may reflect a commonality of central sensitization to their pathophysiology. An important question that still needs to be determined is whether there are individuals with a higher inherited propensity for developing central sensitization than others, and if so, whether this conveys an increased risk in both developing conditions with pain hypersensitivity, and their chronification. Diagnostic criteria to establish the presence of central sensitization in patients will greatly assist the phenotyping of patients for choosing treatments that produce analgesia by normalizing hyperexcitable central neural activity. We have certainly come a long way since the first discovery of activity-dependent synaptic plasticity in the spinal cord and the revelation that it occurs and produces pain hypersensitivity in patients. Nevertheless, discovering the genetic and environmental contributors to and objective biomarkers of central sensitization will be highly beneficial, as will additional treatment options to prevent or reduce this prevalent and promiscuous form of pain plasticity.

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Central sensitization: implications for the diagnosis and treatment of pain.

HLA-DQ Heterodimers in Hematopoietic-Cell Transplantation.

Interference alignment (IA) is a promising technique for interference mitigation in multicell networks due to its ability to completely cancel the intercell interference through linear precoding and receive filtering. In small networks, the amount of required channel state information (CSI) is modest and IA is, therefore, typically applied jointly over all base stations. In large networks, where the channel coherence time is short in comparison to the time needed to obtain the required CSI, base station clustering must be applied however. We model such clustered multicell networks as a set of coalitions, where CSI acquisition and IA precoding are performed independently within each coalition. We develop a long-term throughput model, which includes both CSI acquisition overhead and the level of interference mitigation ability as a function of the coalition structure. Given the throughput model, we formulate a coalitional game where the involved base stations are the rational players. Allowing for individual deviations by the players, we formulate a distributed coalition formation algorithm with low complexity and low communication overhead that leads to an individually stable coalition structure. The dynamic clustering is performed using only long-term CSI, but we also provide a robust short-term precoding algorithm, which accounts for the intercoalition interference when spectrum sharing is applied between coalitions. Numerical simulations show that the distributed coalition formation is generally able to reach long-term sum throughputs within 10% of the global optimum.

Distributed Long-Term Base Station Clustering in Cellular Networks Using Coalition Formation

Downlink Beamformer Design Using Semidefinite Optimization

In this paper, the problem of training optimization for estimating a multiple-input multiple-output (MIMO) flat fading channel in the presence of spatially and temporally correlated Gaussian noise is studied in an application-oriented setup. So far, the problem of MIMO channel estimation has mostly been treated within the context of minimizing the mean square error (MSE) of the channel estimate subject to various constraints, such as an upper bound on the available training energy. We introduce a more general framework for the task of training sequence design in MIMO systems, which can treat not only the minimization of channel estimator's MSE, but also the optimization of a final performance metric of interest related to the use of the channel estimate in the communication system. First, we show that the proposed framework can be used to minimize the training energy budget subject to a quality constraint on the MSE of the channel estimator. A deterministic version of the "dual" problem is also provided. We then focus on four specific applications, where the training sequence can be optimized with respect to the classical channel estimation MSE, a weighted channel estimation MSE and the MSE of the equalization error due to the use of an equalizer at the receiver or an appropriate linear precoder at the transmitter. In this way, the intended use of the channel estimate is explicitly accounted for. The superiority of the proposed designs over existing methods is demonstrated via numerical simulations.

Training Sequence Design for MIMO Channels: An Application-Oriented Approach

Analysis of MIMO Multi-Cell Correlations and Other Propagation Issues Based on Urban Measurements

Mats Bengtsson

Papers

HLA-DQ Heterodimers in Hematopoietic-Cell Transplantation.

Distributed Long-Term Base Station Clustering in Cellular Networks Using Coalition Formation

Downlink Beamformer Design Using Semidefinite Optimization

Training Sequence Design for MIMO Channels: An Application-Oriented Approach

Analysis of MIMO Multi-Cell Correlations and Other Propagation Issues Based on Urban Measurements