M
Mary M. Horowitz
Researcher at Center for International Blood and Marrow Transplant Research
Publications - 579
Citations - 61997
Mary M. Horowitz is an academic researcher from Center for International Blood and Marrow Transplant Research. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 127, co-authored 557 publications receiving 56539 citations. Previous affiliations of Mary M. Horowitz include University of Minnesota & Children's Hospital of Wisconsin.
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Journal ArticleDOI
Graft-versus-leukemia reactions after bone marrow transplantation
Mary M. Horowitz,Robert Peter Gale,Paul M. Sondel,John M. Goldman,J. H. Kersey,HJ Kolb,A. A. Rimm,O Ringden,C. Rozman,Bruno Speck +9 more
TL;DR: The results explain the efficacy of allogeneic bone marrow transplantation in eradicating leukemia, provide evidence for a role of the immune system in controlling human cancers, and suggest future directions to improve leukemia therapy.
Journal ArticleDOI
Defining the intensity of conditioning regimens: working definitions.
Andrea Bacigalupo,Karen K. Ballen,Doug Rizzo,Sergio Giralt,Hillard M. Lazarus,Vincent T. Ho,Jane F. Apperley,Shimon Slavin,Marcelo C. Pasquini,Brenda M. Sandmaier,John Barrett,Didier Blaise,Robert Lowski,Mary M. Horowitz +13 more
TL;DR: This report proposes to define conditioning regimens in 3 categories: (1) myeloablative (MA) conditioning, (2) reduced-intensity conditioning (RIC), and (3) nonmyeloablatives (NMA) Conditioning, based on the duration of cytopenia and on the requirement for stem cell support.
Journal ArticleDOI
Chronic Myeloid Leukemia: An Update of Concepts and Management Recommendations of European LeukemiaNet
Michele Baccarani,Jorge E. Cortes,Fabrizio Pane,Dietger Niederwieser,Giuseppe Saglio,Jane F. Apperley,Francisco Cervantes,Michael W. Deininger,Alois Gratwohl,François Guilhot,Andreas Hochhaus,Mary M. Horowitz,Timothy P. Hughes,Hagop M. Kantarjian,Richard A. Larson,Jerald P. Radich,Bengt Simonsson,Richard T. Silver,John M. Goldman,Rüdiger Hehlmann +19 more
TL;DR: Imatinib should be continued indefinitely in optimal responders and second-generation TKIs are recommended, followed by allogeneic hematopoietic stem-cell transplantation only in instances of failure and, sometimes, suboptimal response, depending on transplantation risk.
Journal ArticleDOI
Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet
Michele Baccarani,Giuseppe Saglio,John M. Goldman,Andreas Hochhaus,Bengt Simonsson,Frederick R. Appelbaum,Jane F. Apperley,Francisco Cervantes,Jorge E. Cortes,Michael W. Deininger,Alois Gratwohl,François Guilhot,Mary M. Horowitz,Timothy P. Hughes,Hagop M. Kantarjian,Richard A. Larson,Dietger Niederwieser,Richard T. Silver,Rüdiger Hehlmann +18 more
Journal ArticleDOI
High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation.
Stephanie J. Lee,John P. Klein,Michael Haagenson,Lee Ann Baxter-Lowe,Dennis L. Confer,Mary Eapen,Marcelo Fernandez-Vina,Neal Flomenberg,Mary M. Horowitz,Carolyn Katovich Hurley,Harriet Noreen,Machteld Oudshoorn,Effie W. Petersdorf,Michelle Setterholm,Stephen R. Spellman,Daniel J. Weisdorf,Thomas M. Williams,Claudio Anasetti +17 more
TL;DR: In multivariate modeling, patient age, race, disease stage, and cytomegalovirus status were as predictive of survival as donor HLA matching, and high-resolution DNA matching for HLA-A, -B, -C, and -DRB1 alleles is associated with higher rates of survival.