M
Matthew Coates
Researcher at Penn State Milton S. Hershey Medical Center
Publications - 37
Citations - 1515
Matthew Coates is an academic researcher from Penn State Milton S. Hershey Medical Center. The author has contributed to research in topics: Inflammatory bowel disease & Medicine. The author has an hindex of 10, co-authored 24 publications receiving 1292 citations. Previous affiliations of Matthew Coates include University of Vermont.
Papers
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Journal ArticleDOI
Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome
Matthew Coates,Christine R. Mahoney,David R. Linden,Joanna E. Sampson,Jason Chen,Hagen Blaszyk,Michael D. Crowell,Keith A. Sharkey,Michael D. Gershon,Gary M. Mawe,Gary M. Mawe,Peter L. Moses +11 more
TL;DR: Findings support the assertion that disordered gastrointestinal function in IBS involves changes intrinsic to the bowel and suggest that shared defects in 5-HT signaling may underlie the altered motility, secretion, and sensation.
Journal ArticleDOI
Review article: intestinal serotonin signalling in irritable bowel syndrome
TL;DR: All aspects of gastrointestinal function involve serotonin signalling between enterochromaffin cells and sensory nerve fibres in the mucosal layer of the gut and potential alterations in mucosal serotonin signalling have been explored.
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Increased Risk of Influenza and Influenza-Related Complications Among 140,480 Patients With Inflammatory Bowel Disease
Andrew Tinsley,Seyedehsan Navabi,Emmanuelle Williams,Guodong Liu,Lan Kong,Matthew Coates,Kofi Clarke +6 more
TL;DR: Inflammatory bowel disease patients had an increased risk of influenza compared with those without IBD and were more likely to require hospitalization, and Steroids were the only medication class independently associated with flu risk.
Journal ArticleDOI
Effects of serotonin transporter inhibition on gastrointestinal motility and colonic sensitivity in the mouse
TL;DR: It is demonstrated that reduced SERT function (via pharmacological blockade) significantly alters GI motility and sensitivity in mice, and support the concept that altered SERT expression and function could contribute to symptoms associated with IBS and IBD.
Journal ArticleDOI
Serotonin signaling in diverticular disease
Meagan Costedio,Matthew Coates,Amy B. Danielson,Thomas R. Buttolph,Hagen Blaszyk,Gary M. Mawe,Neil Hyman +6 more
TL;DR: Alterations in 5-HT signaling do not appear to be responsible for the development of diverticula, however, patients with a recent history of acute diverticulitis have a significant attenuation in SERT expression and function, likely secondary to previous inflammation.