G
Gary M. Mawe
Researcher at University of Vermont
Publications - 174
Citations - 9403
Gary M. Mawe is an academic researcher from University of Vermont. The author has contributed to research in topics: Enteric nervous system & Myenteric plexus. The author has an hindex of 48, co-authored 163 publications receiving 8446 citations. Previous affiliations of Gary M. Mawe include University of Calgary.
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Journal ArticleDOI
Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets
Gary M. Mawe,Jill M. Hoffman +1 more
TL;DR: Emerging evidence suggests that exploiting epithelial targets with nonabsorbable serotonergic agents could provide safe and effective therapies, and this work provides an overview of theseserotonergic actions and treatment strategies.
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Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome
Matthew Coates,Christine R. Mahoney,David R. Linden,Joanna E. Sampson,Jason Chen,Hagen Blaszyk,Michael D. Crowell,Keith A. Sharkey,Michael D. Gershon,Gary M. Mawe,Gary M. Mawe,Peter L. Moses +11 more
TL;DR: Findings support the assertion that disordered gastrointestinal function in IBS involves changes intrinsic to the bowel and suggest that shared defects in 5-HT signaling may underlie the altered motility, secretion, and sensation.
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Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis.
Brian D. Gulbransen,Mohammad Bashashati,Simon A. Hirota,Xianyong Gui,Jane Roberts,Justin A. MacDonald,Daniel A. Muruve,Derek M. McKay,Paul L. Beck,Gary M. Mawe,Roger J. Thompson,Keith A. Sharkey +11 more
TL;DR: It is reported that inflammation causes enteric neuron death by activating a neuronal signaling complex composed of P2X7 receptors, pannexin-1 channels, the Asc adaptor protein and caspases, and it is concluded that activation of neuronal Panx1 underlies neuron death and the subsequent development of abnormal gut motility in IBD.
Journal ArticleDOI
Fundamentals of neurogastroenterology: Basic science
Stephen J. Vanner,Beverley Greenwood-Van Meerveld,Gary M. Mawe,Terez Shea-Donohue,Elena F. Verdu,Jackie D. Wood,David Grundy +6 more
TL;DR: This review examines the fundamentals of neurogastroenterology that may underlie the pathophysiology of functional GI disorders (FGIDs) and emphasizes recent advances in understanding of the enteric nervous system, sensory physiology underlying pain, and stress signaling pathways.
Journal ArticleDOI
Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis.
TL;DR: Altered 5-HT availability may contribute to the dysmotility of inflammatory bowel disease, possibly due to desensitization of 5- HT receptors.