Matthew D. Hale

TL;DR: XGC is a global disease and is associated with GB Ca, and characteristic pathological, radiological and clinical features are shared withGB Ca and contribute to considerable treatment inaccuracy.

TL;DR: The current literature supports the hypothesis that biomarkers derived from the tumour stroma may be useful to predict response to chemotherapy, and appears to be related to the overall quantity and cellularity of the intra-tumoural stroma and the predominant constituents of the extracellular matrix.

TL;DR: This is the first study to suggest preferential HER2 positivity at the luminal surface in GC and to establish a minimum number of biopsy specimens needed to obtain a biopsy HER2 result which is identical to that from the whole tumor.

TL;DR: Better recognition of the relationship between frailty, the wider determinants, inequalities and resilience can enable a framework around which policy responses may be developed to build resilience in people living with frailty at an individual and community level.

TL;DR: Investigation of whether the association between blood pressure and clinical outcomes is different in older adults with and without frailty, using observational studies found no mortality difference for older people with frailty whose systolic blood pressure is <140 mm Hg, compared to those with a syStolicBlood pressure >140mm Hg.