M
Matthew D. Massich
Researcher at Northwestern University
Publications - 9
Citations - 3460
Matthew D. Massich is an academic researcher from Northwestern University. The author has contributed to research in topics: Colloidal gold & Regulation of gene expression. The author has an hindex of 8, co-authored 9 publications receiving 3196 citations. Previous affiliations of Matthew D. Massich include Northwest University (United States).
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Journal ArticleDOI
Gold nanoparticles for biology and medicine.
David A. Giljohann,Dwight S. Seferos,Dwight S. Seferos,Weston L. Daniel,Matthew D. Massich,Pinal C. Patel,Chad A. Mirkin +6 more
TL;DR: This Review highlights recent advances in the synthesis, bioconjugation, and cellular uses of gold nanoconjugates.
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Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation
Dan Zheng,David A. Giljohann,David Chen,Matthew D. Massich,Xiao Qi Wang,Hristo Iordanov,Chad A. Mirkin,Amy S. Paller +7 more
TL;DR: It is shown that spherical nucleic acid nanoparticle conjugates (SNA-NCs), gold cores surrounded by a dense shell of highly oriented, covalently immobilized siRNA, freely penetrate almost 100% of keratinocytes in vitro, mouse skin, and human epidermis within hours after application.
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Gold Nanoparticles for Biology and Medicine
David A. Giljohann,Dwight S. Seferos,Weston L. Daniel,Matthew D. Massich,Pinal C. Patel,Chad A. Mirkin +5 more
TL;DR: Gold colloids have fascinated scientists for over a century and are now heavily utilized in chemistry, biology, engineering, and medicine as mentioned in this paper, and many examples of highly sensitive and selective assays based upon gold nanoconjugates.
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Nano-Flares for mRNA Regulation and Detection
Andrew E. Prigodich,Dwight S. Seferos,Matthew D. Massich,David A. Giljohann,Brandon C. Lane,Chad A. Mirkin +5 more
TL;DR: This work develops an oligonucleotide gold nanoparticle conjugate that is capable of both detecting and regulating intracellular levels of mRNA, and characterize the binding rate and specificity of these materials using survivin, a gene associated with the diagnosis and treatment of cancer, as a target.
Journal ArticleDOI
Regulating immune response using polyvalent nucleic acid-gold nanoparticle conjugates
Matthew D. Massich,David A. Giljohann,Dwight S. Seferos,Louise E. Ludlow,Curt M. Horvath,Chad A. Mirkin +5 more
TL;DR: This study finds that the innate immune response to densely functionalized, oligonucleotide-modified nanoparticles is significantly less when compared to a lipoplex carrying the same DNA sequence.