D
David Chen
Researcher at Northwestern University
Publications - 107
Citations - 6105
David Chen is an academic researcher from Northwestern University. The author has contributed to research in topics: Spinal cord injury & Rehabilitation. The author has an hindex of 29, co-authored 98 publications receiving 5573 citations. Previous affiliations of David Chen include Loma Linda University Medical Center & Houston Methodist Hospital.
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Journal ArticleDOI
Neuronal ensemble control of prosthetic devices by a human with tetraplegia
Leigh R. Hochberg,Leigh R. Hochberg,Mijail D. Serruya,Gerhard Friehs,Gerhard Friehs,Jon A. Mukand,Jon A. Mukand,Maryam Saleh,Abraham H. Caplan,Almut Branner,David Chen,Richard D. Penn,John P. Donoghue +12 more
TL;DR: Initial results for a tetraplegic human using a pilot NMP suggest that NMPs based upon intracortical neuronal ensemble spiking activity could provide a valuable new neurotechnology to restore independence for humans with paralysis.
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Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation
Dan Zheng,David A. Giljohann,David Chen,Matthew D. Massich,Xiao Qi Wang,Hristo Iordanov,Chad A. Mirkin,Amy S. Paller +7 more
TL;DR: It is shown that spherical nucleic acid nanoparticle conjugates (SNA-NCs), gold cores surrounded by a dense shell of highly oriented, covalently immobilized siRNA, freely penetrate almost 100% of keratinocytes in vitro, mouse skin, and human epidermis within hours after application.
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Medical complications during acute rehabilitation following spinal cord injury—current experience of the model systems☆☆☆
TL;DR: The continued declining lengths of acute care hospitalization after SCI have resulted in the occurrence in the rehabilitation setting of medical complications that were previously seen in acute care.
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Prevention of thromboembolism after spinal cord injury using low-molecular-weight heparin
David Green,Michael Y. Lee,Ai Chi Lim,Joan S. Chmiel,Marsha Vetter,Thomas Pang,David Chen,Lynne L. Fenton,Gary M. Yarkony,Paul R. Meyer +9 more
TL;DR: Low-molecular-weight heparin is safe and effective in the prevention of thromboembolism in selected patients with spinal cord injury and complete motor paralysis, and is superior to standard Heparin in fixed doses of 5000 units three times a day.
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Impact of Respiratory Complications on Length of Stay and Hospital Costs in Acute Cervical Spine Injury
TL;DR: The number of respiratory complications experienced during the initial acute-care hospitalization for CSI is a more important determinant of LOS and hospital costs than level of injury.