M
Matthew D. Petroski
Researcher at California Institute of Technology
Publications - 7
Citations - 2501
Matthew D. Petroski is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Ubiquitin ligase & Cell division control protein 4. The author has an hindex of 6, co-authored 6 publications receiving 2337 citations.
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Journal ArticleDOI
Function and regulation of cullin-RING ubiquitin ligases.
TL;DR: This review focuses on the composition, regulation and function of cullin–RING ligases, and describes how these enzymes can be characterized by a set of general principles.
Journal ArticleDOI
Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34
TL;DR: It is proposed that the acidic loop favorably positions K48 of a substrate-linked ubiquitin to attack SCF bound Cdc34 approximately ubiquit in thioester and thereby enables processive synthesis of K48-linked Ubiquitin chains by SCF-Cdc34.
Journal ArticleDOI
Context of multiubiquitin chain attachment influences the rate of Sic1 degradation.
TL;DR: It is revealed that a single multiubiquitin chain can sustain a physiological turnover rate, but that chain position plays an unexpectedly significant role in the rate of proteasomal proteolysis.
Book ChapterDOI
In Vitro Reconstitution of SCF Substrate Ubiquitination with Purified Proteins
TL;DR: This chapter describes the methodologies employed to reconstitute ubiquitination of the budding yeast cyclin-dependent kinase inhibitor Sic1 by the evolutionarily conserved ubiquitin ligase SCF(Cdc4) and its ubiqu itin-conjugating enzyme Cdc34.
Journal ArticleDOI
Evaluation of a Diffusion-Driven Mechanism for Substrate Ubiquitination by the SCF-Cdc34 Ubiquitin Ligase Complex
TL;DR: It is proposed that interactions between Cdc34 Approximately Ub and SCF directly activate ubiquitin transfer within a substrate-SCF-Cdc34 approximately Ub ternary complex.